Monoclonal antibody recognizing alpha 2.fwdarw.3 bonds

Details Monoclonal antibody recognizing alpha 2.fwdarw.3 bonds Monoclonal antibody recognizing alpha 2.fwdarw.3 bonds

1988-11-14

1992-08-25

Doll, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

424 858, 424 8591, 435 7021, 4351722, 43524027, 53038885, 530864, 935104, 935107, C12N 520, C07K 1528

Patent

active

051418649

ABSTRACT:
A hybridoma capable of producing a monoclonal antibody specific to a sialic acid containing glycolipid carrying N-acetylneuraminic acid residue having alpha 2.fwdarw.3 linkage is herein disclosed. The hybridoma can be generated by fusing (i) B cells or lymphocytes obtained by immunizing an animal with a sialic acid containing glycolipid carrying N-acetylneuraminic acid residue having alpha 2.fwdarw.3 linkage and (ii) myeloma cells. The monoclonal antibody produced by the hybridoma can be used for purifying gangliosides, for treating patients suffering from melanoma and for diagnosing sera.

REFERENCES:
Hersey, P. et al., "Potentiation of Lymphocyte Responses by Monoclonal Antibodies to the Ganglioside GD3", Cancer Research 46:6083-6090, Dec. 1986.
"A Course of Experiments on the Biochemistry" pp. 1-2.
Eur. J. Immunol., vol. 16, 1986, pp. 951-956, "Production of oligosaccharide-binding monoclonal antibodies of diverse . . . ".
J. Exp. Med., vol. 150, Oct. 1979, pp. 1008-1019, "Production of monoclonal antibodies specific for two distinct . . . ".

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