Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1992-05-08
1995-08-15
Saunders, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 724, 4351722, 43524027, 436548, 53038873, C07K 1528, G01N 33574, G01N 33577
Patent
active
054418712
ABSTRACT:
A leukemia lymphoma reactive monoclonal antibody which, relative to normal peripheral blood cells, strongly reacts with one or more leukemia lymphoma cell specimens selected from the group consisting of B non-Hodgkin's lymphoma cells, B chronic lymphocytic leukemia cells, B prolymphocytic leukemia cells, B hairy cell leukemia cells, and B acute lymphoblastic leukemia cells. More specifically, a novel hybrid cell line, designated 2B-4G9, for production of monoclonal antibody specific for a unique cell surface epitope associated with a wide variety of human lymphomas and leukemias is provided. This invention also provides a method for producing the new monoclonal antibody and to diagnostic procedures using the new monoclonal antibody to detect various leukemias and lymphomas. Also disclosed are methods of using the antibody or reactive fragments of the antibody for the treatment of leukemia-lymphoma patients.
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Dunn Michael L.
Health Research , Inc.
Saunders David
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