Monoclonal antibody - platinum co-ordination compound complex

Details Monoclonal antibody - platinum co-ordination compound complex Monoclonal antibody - platinum co-ordination compound complex

1988-04-21

1990-09-11

Draper, Garnette

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530390, 530391, 530388, 530808, 424 859, 424 8591, 514885, C07K 1512, A61K 3900

Patent

active

049564544

ABSTRACT:
Platinum co-ordination compounds comprising at least one amine ligand and a functional group remotely bonded to the amine ligand, which functional group may be linkable to a monoclonal antibody to provide a moiety which stabilizes the antibody against in vivo hydrolysis.

REFERENCES:
patent: 4614811 (1986-09-01), Gandalfi
patent: 4658048 (1987-04-01), Totani et al.
patent: 4661516 (1987-04-01), Brown et al.
patent: 4793986 (1988-12-01), Serino et al.
Monoclonal Antibodies and Cancer Therapy, ed. Reisfeld et al, 1985, pp. 245-246 and 251-252.

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