Monoclonal antibody panel for early diagnosis and therapy of ren

Details Monoclonal antibody panel for early diagnosis and therapy of ren Monoclonal antibody panel for early diagnosis and therapy of ren

1984-05-04

1987-12-15

Marantz, Sidney

Chemistry: analytical and immunological testing

Involving production or treatment of antibody

Monoclonal antibody

436501, 436811, 436813, 530387, 424 85, G01N 3353, G01N 33566

Patent

active

047133520

ABSTRACT:
A panel of monoclonal antibodies is developed for use in diagnosis and treatment of renal carcinoma. One monoclonal antibody F.sub.31 reacts with 80% of renal carcinoma. The area of overlap of reactivity of monoclonal antibodies F.sub.31, F.sub.23, S.sub.4, S.sub.23 and S.sub.27 is the site of origin of most renal carcinomas. Reactivity with this panel of monoclonal antibodies localizes most renal carcinoma and is a vehicle for early diagnosis and treatment.

REFERENCES:
Ueda, R. et al, (1981), Proc. Natl. Acad. Sci. USA, 78, No. 8: 5122-5126.
Fradet, Y. et al., (1984), Proc. Natl. Acad. Sci. USA, 81: 224-228.
Lennox, E. et al, (1982), in "Monoclonal Antibodies in Medicine" (McMichael and Fabre, Eds), Academic Press, Chapter 5, pp. 111-128.

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