Monoclonal antibody, measuring method of glucosylated protein by

Details Monoclonal antibody, measuring method of glucosylated protein by Monoclonal antibody, measuring method of glucosylated protein by

1987-01-14

1989-06-06

Marantz, Sidney

Chemistry: analytical and immunological testing

Involving production or treatment of antibody

Monoclonal antibody

4351722, 43524027, 436 67, 436808, 436811, 530387, 935110, G01N 33577, G01N 3366

Patent

active

048371700

ABSTRACT:
For the diagnosis of diabetes, a glucosylated protein in a sample is measured by subjecting the sample to a reducing treatment and then detecting a compound, which contains one or more reduced glucosylated lysine residual groups, in accordance with an immunoassay technique in which the reduced glucosylated lysine residual groups are used as an epitope.

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Witztum et al., "Nonenzymatic Glucosylation of Low-Density Lipoprotein Alters Its Biologic Activity", Diabetes, 31, 283-291 (1982).
Steinbrecher et al.; "Glucosylation of Low-Density Lipoproteins to an Extent Comparable to That Seen in Diabetes Slows . . . " Diabetes, 33, 130-134 (1984).
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Curtis et al.; "A Novel Method for Generating Region-Specific . . . " J. Clin. Invest., 72, 1427-1438 (1983).

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