Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1990-06-12
1992-07-14
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 792, 435973, 43524027, 436501, 436811, 53038835, 5303894, C12Q 170, C12Q 100, G01N 3353, C12N 500, A61K 3514, C07K 300, C07K 1300, C07K 1500
Patent
active
051302322
ABSTRACT:
The combination of monoclonal antibodies 11A25 and 11E32, which recognize two distinct antigenic sites on the 62-kd glycoprotein of reticuloendotheliosis virus (REV) in ELISA, enables an increase in the sensitivity of an ELISA assay for subtype 2 REV over what was heretofore possible. The combination of MAbs is useful for diagnosing REV antigen and antibody in poultry flocks and for detecting new strains and variants of the viral subtype.
REFERENCES:
patent: 4514505 (1985-04-01), Cranfield et al.
Cho (1983) Cytopathic Effects and Focus Formation-Avian Dis 27:261-270.
Cui et al. (1986) Monoclonal Antibodies Against AEV-J. Immunol 136:4237-42.
Cui et al. (1988) Monoclonal Ab. Mediated Elisa-Avian Disease 32: 32-40.
Zhi-Zhong Cui et al., "Monoclonal Antibodies Against Avian Reticuloendotheliosis Virus: Identification of Strain-Specific and Strain-Common Epitopes", J. Immunol. 136(11): 4237-4242 (Jun. 1, 1986).
Zhizhong Cui et al., "Monoclonal-Antibody-Mediated Enzyme-Linked Immunosorbent Assay for Detection of Reticuloendotheliosis Viruses", Avian Dis. 32: 32-40 (1988).
Cui Zhizhong
Lee Lucy F.
Witter Richard L.
Fado John D.
Nucker Christine M.
Preston D. R.
Ribando Curtis P.
Silverstein M. Howard
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