Monoclonal antibody for use in drug resistant cancers and produc

Details Monoclonal antibody for use in drug resistant cancers and produc Monoclonal antibody for use in drug resistant cancers and produc

1990-10-01

1992-02-11

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 7021, 4351722, 43524027, 435103, 435106, 435107, 530387, C12G 168, C12P 2100, C12N 1500

Patent

active

050875604

ABSTRACT:
Monoclonal antibodies are disclosed that may be produced by hybridomas obtained by fusing a mouse spleen cell immunized with an ADRIAMYCIN.RTM.-resistant human tumor cell and a mouse myeloma cell and which inhibit selectively the growth of cancer cells possessing pleiotropic drug resistance or enhance their sensitivity to said drug.

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Kartner et alii. Science, vol. 221: 1285-1288 (Jul./Sep. 1983).
Young et alii. Prog. Clin. Biol. Res. 1983; pp. 293-304 abstract only.
N. Young et al.., Globin Gene Expression and Hematopoietic Differentiation, pp. 293-304, 1983 Alan R. Liss, Inc., New York, N.Y.
Chem. Abs., vol. 100 (9):443; 6295q (2/27/84).
Chem. Abs.; vol. 104(5): 43; 3285h (2/3/86).
Proc. Natl. Acad. Sci. U.S.A., vol. 83: 7785-7789 (1986).
Kartner, N. et al. Nature vol. 316, Aug. 29, 1985 pp. 820-823.
Galfre, G. & Milstein, C., Methods in Enzymology, 73:3-45, 1981.
Tsuruo, T. et al., Gann, 74:751-758, 1983.
Kearney, F. et al., The Journal of Immunology, 123 (4):1548-1550, 1979.

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