Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1983-06-29
1987-12-01
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 43, 435 68, 4351722, 43524027, 435948, 530387, 935 84, 935 95, 935 99, 935100, 935101, 935103, 935104, 935105, 935106, 935108, 424 85, 424 86, 424 87, G01N 3353, G01N 33577, C12P 3700
Patent
active
047104570
ABSTRACT:
This invention concerns a new monoclonal antibody (mAb) 4C, recognizing a specific antigen, Leu 200, found in human hematopoietic tissues. The monoclonal antibody precipitates a series of glycoproteins (Leu 200) with a molecular weight range of about 190,000 to 230,000 from both T- and B-cell lines. The series of glycoproteins resolves into four discrete glycoprotein bands, the distribution of which varies according to the cell lines. Bands 3 and 4 predominate in a majority of T-cells whereas band 2 predominates in B cells. Thus, a Leu 200 antigen subset distribution is possible with mAb 4C. Bands 1, 2, 3, 4 have apparent molecular weights of 230K, 215K, 205K, and 190K respectively, with differences in their carbohydrate moieties. mAb 4C is a IgG sub two a, kappa immunoglobulin. 4C has potential use in leukemia, hematopoietic cell differentiation and transplantation diagnoses and therapy.
REFERENCES:
Omary et al, J. Exp. Med., vol. 152, Oct. 1980, pp. 842-852.
Marishima et al, Immunogenetics, vol. 85, 529-535, 1982.
Collins Nancy
Dupont Bo
Lloyd Kenneth O.
Morishima Yasuo
Ogata Shun-ichiro
Nucker Christine M.
Sloan-Kettering Institute for Cancer Research
White John P.
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