Monoclonal antibody for human hematopoietic glycoproteins and me

Chemistry: molecular biology and microbiology – Spore forming or isolating process

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4351722, 435 7021, 935 95, 935100, 935101, 935103, 935104, 935105, 530387, C12N 1500

Patent

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048928283

ABSTRACT:
This invention concerns a new monoclonal antibody (mAb) 4C, recognizing a specific antigen, Leu 200, found in human hematopoietic tissues. The monoclonal antibody precipitates a series of glycoproteins (Leu 200) with a molecular weight range of about 190,000 to 230,000 from both T- and B-cell lines. The series of glycoproteins resolves into four discrete glycoprotein bands, the distribution of which varies according to the cell lines. Bands 3 and 4 predominate in a majority of T-cells whereas band 2 predominates in B cells. Thus, a Leu 200 antigen subset distribution is possible with mAb 4C. Bands 1, 2, 3, 4 have apparent molecular weights of 230K, 215K, 205K, and 190K respectively, with differences in their carbohydrate moieties. nAb 4C is a IgG sub two a,kappa immunoglobulin. 4C has potential use in leukemia, hematopoietic cell differentiation and transplantation diagnoses and therapy.

REFERENCES:
Morishima et al., Immunogenetics, vol. 85, 529-535, 1982.
Omary et al., J. Exp. Med., vol. 152, Oct. 1980, pp. 842-852.

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