Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2005-07-30
2010-10-19
Wen, Sharon (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387100, C530S387700, C530S387900
Reexamination Certificate
active
07816498
ABSTRACT:
Provided is a monoclonal antibody specific for hippuric acid. In the present invention, a hippuric acid-carrier protein conjugate is prepared from hippuric acid and BSA or OVA as a carrier protein, using a coupling reagent and a cross-linker. The monoclonal antibody screened according to the present invention has a titer having a standard curve in the concentration range of mg/mL meeting requirements for the permissible exposure limit (PEL) of toluene. The monoclonal antibody exhibits no cross-reactivity with carrier proteins, exhibits higher competitive inhibition in response to an increasing concentration of hippuric acid, and exhibits no cross-reactivity with other proteins contained in the urine. Therefore, the disclosed monoclonal antibody can be usefully employed in a diagnostic kit for detection of hippuric acid which is capable of diagnosing toluene exposure.
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Chung Hee Sun
Kwon Oh Hyep
Lee Seung Hwa
Tae Gun Sik
Christie Parker & Hale LLP
HBI Co., Ltd.
Tae Gun Sik
Wen Sharon
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