Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Reexamination Certificate
2008-01-22
2008-01-22
Foley, Shanon (Department: 1642)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
C424S138100, C424S141100, C424S155100, C424S179100, C424S180100
Reexamination Certificate
active
10620091
ABSTRACT:
A novel anti-polyethylene glycol monoclonal antibody and its preparation are disclosed. Such an antibody can be used for determining polyethylene glycol concentration in vitro or accelerating the clearance of a polyethylene glycol containing compound from the blood circulation in the human body thereby reducing the toxicity associated with the polyethylene glycol containing conjugate. The antibody is particularly useful in cancer therapy where the therapeutic agent is selectively delivered to the tumor by increasing the tumor/blood ratio of the polyethylene glycol containing compound.
REFERENCES:
patent: 4427653 (1984-01-01), Springer
patent: 6077499 (2000-06-01), Griffiths et al.
Cheng et al. (Cancer Imunol. Immunother. 1997; 44: 305-315).
Cheng et al. (Bioconjugate Chem. 1999; 10: 520-528).
Richter et al. (Int. Archs Allergy Appl. Immun. 1983: 70; 124-131).
Hershfield et al. (Proc. Natl. Acad. Sci. 1991; 88: 7185-7189).
Melton et al. (Journal of the National Cancer Institute 1996; 88: 153-165).
Jung et al. (Mini Reviews in Medicinal Chemistry 2001; 1: 399-407).
Klibanov et al., “Blood Clearance of Radiolabeled Antibody: Enhancement by Lactosamination and Treatment with Biotin-Avidin or Anti-Mouse IgG Antibodies”, pp. 1951-1956,The Journal of Nuclear Medicine, vol. 29, No. 12, Dec. 1988.
Yao et al., “Improved Targeting of Radiolabeled Streptavidin in Tumors Pretargeted with Biotinylated Monoclonal Antibodies through an Avidin Chase”, pp. 837-841,The Journal of Nuclear Medicine, vol. 36, No. 5, May 1995.
Guermant et al., “Quantitative Determination of Polyethylene Glycol Based Upon Its Salting Out and Partioning of a Dye into the Resulting Aqueous Two-Phase System”, pp. 254-258,Analytical Biochemistry230, (1995).
Kerr et al., “Application of Monoclonal Antibodies Against Cytosine Deaminase for the In Vivo Clearance of a Cytosine Deaminase Immunoconjugate”, pp. 353-357,Bioconjugate Chem., vol. 4, No. 5, (1999).
Pedley et al., “The Effect of Second Antibody Clearance on the Distribution and Dosimetry of Radiolabelled Anti-Cea Antibody in a Human Colonic Tumor Xenograft Model”, pp. 713-718,Int. J. Cancer43, (1989).
Sharkey et al., “Enhanced Clearance of Radiolabeled Murine Monoclonal Antibody by a Syngeneic Anti-idiotype Antibody in Tumor-Bearing Nude Mice”, pp. 266-273,Int. J. Cancer, 51 (1992).
Kinahan et al., “High-Performance Liquid Chromatographic Determination of PEG 600 in Human Urine”, pp. 297-307,Journal of Chromatography, 565, (1991).
Ruddy et al., “High-Performance Liquid Chromatographic Method for the Simultaneous Determination of Low-Molecular-Mass Oligomers of Polyethylene Glycol in Aqueous Skin Extracts”, pp. 83-92,Journal of Chromatography B., 657 (1994).
Kobabayshi et al., “Comparison of the Chase Effects of Avidin, Streptavidin, Neutravidin, and Avidin-Ferritin on a Radiolabeled Biotinylated Anti-Tumor Monoclonal Antibody”, pp. 310-314,Jpn. J. Cancer Res., 86, Mar. 1995.
Zhang et al., “Intravenous Avidin Chase Improved Localization of Radiolabeled Streptavidin in Intraperitoneal Xenograft Pretargeted With Biotinylated Antibody”, pp. 61-64,Nuclear Medicine&Biology, vol. 24 (1997).
Sharkey et al., “Second Antibody Clearance of Radiolabeled Antibody in Cancer Radioimmunodetection”, pp. 2843-2846,Proc. Natl. Acad. Sci. USA, vol. 81, May 1985.
Nag et al., “A Colorimetric Assay for Estimation of Polyethylene Glycol and Polyethylene Glycolated Protein Using Ammonium Ferrothiocyanate”, pp. 224-231,Analytical Biochemistry, 237, (1996).
Cheng et al., “Accelerated Clearance of Polyethylene Glycol-Modified Proteins by Anti-Polyethylene Glycol IgM”, pp. 520-528,Bioconjugate Chemistry, vol. 10, No. 3, 1999.
Cheng et al., “Efficient Clearance of Poly(ethylene glycol)- Modified Immunoenzyme with Anti PEG Monoclonal Antibody for Prodrug Cancer Therapy”, pp. 258-266,Bioconjugate Chemistry, vol. 11 No. 2 (2000).
Rogers et al., “Plasma Clearance of an Antibody-enzyme Conjugate in ADEPT by monoclonal Anti-Enzyme: Its Effect on Prodrug Activation in vivo”, pp. 1357-1363,British Journal of Cancer, 72, (1995).
Ryan et al., “Separation and Quantitation of Polyethylene Glycols 400 and 3350 from Human Urine by High Performance Liquid Chromatography”, pp. 350-351,Journal of Pharmaceutical Sciences, 351, vol. 81, No. 4, Apr. 1992).
Marshall et al., “Galactosylated Streptavidin for Improved Clearance of Biotinylated Intact and F(ab′)2 Fragments of an Anti-Tumor Antibody”, pp. 18-24,British Journal of Cancer, 71, (1995).
Sharma et al., “Inactivation and Clearance of an Anti-CEA Carboxypeptidase G2 Conjugate in Blood After Localization in a Xenograft Model”, pp. 659-662,British Journal of Cancer, 61, (1990).
Stocks, et al., “A Fluorometric Assay of the Degree of Modification of Protein Primary Amines with Polyethylene Glycol”, pp. 232-234,Analytical Biochemistry, 154, (1986).
Cheng Tian-Lu
Roffler Steve
Wu Pin-Yi
Academia Sinica
Cohen Pontani Lieberman & Pavane LLP
Fetterolf Brandon
Foley Shanon
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