Monoclonal antibody capable of binding to heparin-binding...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C424S133100, C424S141100, C424S145100, C435S069600, C435S070210, C530S387300, C530S388100, C530S388220

Reexamination Certificate

active

07851601

ABSTRACT:
Medicaments for treating diseases related to HB-EGF escalation are in demand. The present invention provides a monoclonal antibody or an antibody fragment thereof which binds to a cell membrane-bound HB-EGF, a membrane type HB-EGF and a secretory HB-EGF.

REFERENCES:
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Supplementary European Search Report dated Mar. 23, 2010 in European Application No. 07744826.4.
Khong et al., “Inhibition of heparin-binding epidermal growth factor-like growth factor increases albuminuria in puromycin aminonucleoside nephrosis,” Kidney International, vol. 58, No. 3, pp. 1098-1107 (2000).
Kipriyanov et al., “Generation and Production of Engineered Antibodies,” Molecular Biotechnology, vol. 26, No. 1, pp. 39-60 (2004).
Miyamoto et al., “Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy,” Cancer Science, vol. 97, No. 5, pp. 341-347 (2006).
Miyamoto et al., “Heparin-Binding EGF-Like Growth Factor Is a Promising Target for Ovarian Cancer Therapy,” Cancer Research, vol. 64, No. 16, pp. 5720-5727 (2004).
Adams et al., “Monoclonal antibody therapy of cancer,” Nature Biotechnology, vol. 23, No. 9, pp. 1147-1157 (2005).

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