Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1993-05-05
1996-02-13
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
5303873, 5303875, 5303888, 4351722, 435 7021, 4352402, C12N 520, C07K 1630
Patent
active
054910889
ABSTRACT:
The present invention relates to novel antibodies reactive with human carcinoma cells. More particularly, the antibodies of the invention include: a murine monoclonal antibody, BR96; a human/murine chimeric antibody, ChiBR96; and a F(ab').sub.2 fragment of BR96. These antibodies are reactive with a cell membrane antigen on the surface of human carcinomas. The antibodies display a high degree of selectivity for carcinoma cells and possess the ability to mediate ADCC and CDC activity. In addition, the antibodies of the invention internalize within the carcinoma cells to which they bind. The antibodies also have a unique feature in that they are cytotoxic when used in the unmodified form, at specified concentrations.
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Bruce Kim F.
Hellstrom Ingegerd
Hellstrom Karl E.
Schreiber George J.
Hutzell Paula K.
Oncogen Limited Partnership
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