Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1994-05-06
1996-06-11
Adams, Donald E.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241301, 4241381, 4241721, 4241781, 4241811, 435 71, 435 792, 4351722, 5303888, A61K 3516, A61K 3900, A61K 39395
Patent
active
055253377
ABSTRACT:
Monoclonal antibody K1 binds to an epitope on the surface of cells of some human tumors, but not to many important normal tissues. Unlike similar antigenic sites such as CA125, this epitope is not shed into the plasma of patients with mesothelioma, e.g. with ovarian cancer. Since the K1 monoclonal antibody is therefore not neutralized by circulating antigen immediately upon injection into the bloodstream, and since K1 allows efficient entry of coupled toxins into cells, the K1 monoclonal antibody can be used in the diagnosis of mesotheliomas.
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Kurrasch, Regina H., et al., "Characterization of a Monoclonal Antibody, OVB1, Which Binds to a Unique Determinant in Human Ovarian Carcinomas and Myeloid Cells", The Journal of Histochemistry and Cytochemistry, vol. 37, pp. 57-67, 1989.
Chang Kai
Pastan Ira
Willingham Mark C.
Adams Donald E.
The United States of America as represented by the Department of
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