Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-06
1997-04-15
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 74, 435 79, 435 792, 435338, 435343, 435337, 53038826, 5303881, G01N 3353
Patent
active
056208561
ABSTRACT:
The invention provides method and kits for detecting a metallic cation in a sample of a body fluid. The preferred method and kits include the use of at least two different types of antibodies having different specificities. In the preferred method, the sample of body fluid can be contacted with an effective amount of a capture antibody specific for a naturally occurring polypeptide that can bind the metallic cation to form a first antigen-antibody complex. An effective amount of an antibody specific for an epitope on a metallic cation-naturally occurring polypeptide complex or an antibody specific for a metallic cation is added to the first antigen-antibody complex to form a second antigen-antibody complex. The amount of the metallic cation in the sample of body fluid is determined by detecting the amount of the second antigen-antibody complex.
REFERENCES:
patent: 4530786 (1985-07-01), Dunbar et al.
patent: 4722892 (1988-02-01), Meares et al.
patent: 4769320 (1988-09-01), Furie et al.
patent: 4859613 (1989-08-01), Lawrence
patent: 5011912 (1991-04-01), Hopp et al.
patent: 5112606 (1992-05-01), Shiosaka et al.
patent: 5354652 (1994-10-01), Silbergeld
Benkovic, Annu. Rev. Biochem., 61: 29-54 (1992).
Lerner, et al., Science, 252: 659-667 (1991).
Nakayama, et al., Catalytic Antibodies, Ciba Foundation Symposium 159: 72-91 (1991).
Sakai, et al., Clin. Chem., 26: 625-628 (1980).
Schultz, et al., The Robert A. Welch Foundation Conferance on Chemical Research, Chemistry at the Frontiers of Medicine, 15: 19-42 (1991).
Wade, et al., J. Am. Chem. Soc., 115: 4906-4907 (1993).
Baker et al., J. Biol. Chem., 253, 8444-8451 (1978).
Bishop et al., PNAS-USA, 83, 5568-5572 (1986).
Chisholm et al., Clin. Chem., 31, 601-605 (1985).
Clarke et al., J. Immunol. Methods, 137, 65-72 (1991).
Fukano et al., Biological Abstracts, 87, Abs. No. 10613 (1989).
Iverson et al., Science, 243, 1184-1188 (1989).
Jaffe et al., Biological Trace Element Research, 28, 223-231 (1991).
Klein, Immunology: The Science of Self-Nonself Discrimination, 348 (1982).
Lewis et al., Scand. J. Immunol., 3, 277-285 (1974).
Lindgarde et al., Scand. J. Immunol., 3, 277-285 (1974).
Merlini et al., Clin. Exp. Immunol., 69, 148-156 (1987).
Reardan, Dialog Information Services, File 35: Dissertation Abstracts Online 1861 Jun. 90, Dialog accession No. 894111, vol. 46/07-B of Dissertation Abstracts International, p. 2326, (1985).
Reardan et al., Nature, 316, 265-267 (1985).
Schuster et al., Biologie Prospective, C.R. Colloq. 8th, 371-376 (1993).
Shirakawa et al., Clin. Exp. Allergy, 22, 213-218 (1992).
Wade et al., J. Am. Chem. Soc., 115, 4449-4456 (1993).
Waters et al., DOE Methods for Evaluating Environmental and Waste Management Samples, (1993).
Waters et al., Govt. Reports Announcements & Index, Issue 24 (1993).
Wylie et al., Anal. Biochem., 194, 381-387 (1991).
Wylie et al., PNAS-USA, 89, 4104-4108 (1992).
BiMelyze.RTM. Mercury Assay Kit sales brochure available to the public in Dec. 1990.
Advertisement for BiMelyze.RTM. Mercury Assay Kit published in the Mar./Apr. 1991 issue of Journal of Analytical Toxicology (vol. 15).
Advertisement for BiMelyze.RTM. Mercury Assay Kit published in the Sep. 1991 issue of Journal of the American Water Works Association (vol. 15).
BiMelyze.RTM. Mercury Assay Protocol.
Alessio et al., "Behavior of Indicators of Exposure and Effect After Cessation of Occupational Exposure to Lead", British J. Ind. Med., 38: 262-267 (1981).
Astrin et al., ".delta.-Aminolevulinic Acid Dehydratase Isozymes and Lead Toxicity", Ann Ny Acad. Sci., 514, 23 (1987).
Baltrop et al., "Lead Binding to Human Haemoglobin", Experientia, 28, 76 (1972).
Bernard et al., "Metal-Induced Alterations of .delta.-Aminolevulinic Acid Dehydratase", Ann. NY Acad. Sci., 51, 41-47 (1987).
Dresel et al., "Studies on the Biosynthesis of Blood Pigments", Biochem. J., 63:72 (1956).
Erikson, "The Extraction of the Urinary Coproporphyrin Chromogen and the Conversion of the Chromogen to Porphyrin", Scand J. Clinc. Lab. Investigations, 4, 55-62 (1952).
Friguet et al., "Measurements of the True Affinity Constant in Solution of Antigen-Antibody Complexes by Enzyme-Linked Immunosorbent Assay", J. Immunol. Methods, 77, 305 (1985).
Fuhr et al., "Nuclear Magnetic Resonance Studies of the Solution Chemistry of Metal Complexes. IX. The Binding of Cadmium, Zinc, Lead, and Mercury by Glutathione", J. Am. Chem. Soc., 95, 6944 (1973).
Fujita et al., "Evidence of Increased Synthesis of .delta.-Aminoleuvulinic Acid Dehydratase in Experimental Lead-Poisoned Rats", Biochem. Biophys. Acta, 678, 39-50 (1981).
Goldberg et al., "Studies on the Biosynthesis of Heme in Vitro by Avian Erythrocytes", Blood, 11, 821 (1956).
Gercken et al., "Determination of Lead and Other Trace Element Species in Blood by Size Exclusion Chromatography and Inductively Coupled Plasma/Mass Spectrometry", Anal. Chem., 63:283-287 (1991).
Hernberg et al., "Enzyme Inhibition by Lead Under Normal Urban Conditions", Lancet, I, 63-66 (1970).
Jaffe et al., "Reevaluation of a Sensitive Indicator of Early Lead Exposure", Biol. Trace Element Res., 28, 223-232 (1991).
Karin, "Metallothionenins: Proteins in Search of Function", Cell, 41, 9 (1985).
Mauzerall et al., "The Occurrence and Determination of .delta.-Aminolevulinic Acid and Porphobilinogen in Urine" J. Biol. Chem., 219, 435 (1956).
Schlick et al., "The Action of Small Doses of Lead on Erthrocyte D-Aminolevulinic Acid Dehydratase in the Mouse", Arch. Toxicol., 43, 213 (1980).
Tsukomoto et al., "The Role of Zinc with Special Reference to the Essential Thiol Groups in .delta.-Aminolevulinic Acid Dehydratase of Bovine Liver", Biochem. Biophys. ACTA, 570, 167-178 (1979).
Church et al., J. Biol. Chem., 263:6259 (1988).
Church et al., J. Biol. Chem., 264:7882 (1989).
Church et al., Blood, 74:2418 (1989).
Nakamura et al., Biochim. Biophys. Acta, 925:85 (1987).
Ohlin et al., J. Biol. chem., 262:13798 (1987).
Ohlin et al., J. Biol. Chem., 263:7411 (1988).
Orthner et al., J. Biol. Chem., 264:18781 (1989).
Stearns et al., J. Biol. Chem., 263:826 (1988).
Wakabayashi et al., J. Biol. Chem., 261:11097 (1986).
Borowski et al., J. Biol. Chem., 261:14969 (1986).
Furie et al., J. Biol. Chem., 253:8980 (1978).
Furie et al.,J. Biol. Chem., 254:9766 (1979).
Lewis et al., Biochemistry, 22:948 (1983).
Madar et al., J. Biol. Chem., 257:1836 (1982).
Malhotra, Biochem. Cell Biol., 68:705 (1990).
Owens et al., J. Biol. Chem., 259:13800 (1984).
Pollock et al., J. Biol. Chem., 263:14216 (1988).
Stenflo, J. Biol. Chem., 247:8167 (1972).
Tai et al., J. Biol. Chem., 255:2790 (1980).
Tai et al., J. Biol. Chem., 259:4162 (1984).
Liebman et al., J. Biol. Chem., 262:7605 (1987).
Smith et al., Am. J. Clin. Pathol., 87:370 (1987).
Tharakan et al., Vox Sang, 58:21 (1990).
Velander et al., Biotechnology Progress, 5:119 (1989).
Ware et al., J. Biol. Chem., 264:11401 (1989).
Arquilla et al., Biochem. J., 175:289 (1978).
Dardenne et al., PNAS USA, 82:7035 (1985).
Higashiyama et al., Biochemistry, 26:7450 (1987).
Mesna et al., Comp. Biochem. Physiol., 99:181 (1991).
Pfyffer et al., J. Neurochem., 49:442 (1987).
Schwabacher et al., J. Am. Chem. Soc., 111:2344 (1989).
Shirakawa et al., CHEST, 95:29 (1989).
Shirakawa et al., Clinical Allergy, 18:451 (1988).
Van Houdt et al., Immunology Letters, 32:21 (1992).
Ward et al., Molecular Immunology, 29:83 (1992).
Carlson Randall R.
Riddell Malcolm
Stout Jay S.
Wagner Fred W.
Wylie Dwane E.
BioNebraska, Inc.
Scheiner Toni R.
LandOfFree
Monoclonal antibody assay and kit for detecting metal cations in does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibody assay and kit for detecting metal cations in, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibody assay and kit for detecting metal cations in will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-360048