Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-08-08
2006-08-08
Le, Long V. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C435S007200, C435S007210, C435S007240, C435S007900, C435S007920, C435S070210, C435S452000, C435S332000, C435S334000, C435S343200, C435S975000, C436S518000, C436S524000, C436S528000, C436S529000, C436S548000, C530S388200, C530S388220, C530S388700, C530S388750, C530S391100, C530S391300
Reexamination Certificate
active
07087396
ABSTRACT:
A method for determining a soluble human ST2 in a sample conveniently at a high sensitivity and an assay kit are provided. By an immunological method comprising a step for bringing a sample into contact with an immobilized antibody formed by binding to an insoluble support a first anti-human ST2 antibody which binds specifically to a non-denatured human ST2, a step for labelling a first reaction product generated in the previous step by reacting said first reaction product with a second anti-human ST2 antibody which binds specifically to a non-denatured human ST2 by recognizing a site different from the site on ST2 where said first anti-human ST2 antibody binds and which is labelled with a label, and a step for determining the amount of the label on said first reaction product which has been labelled, a soluble human ST2 in a sample is determined. In addition, a recombinant ST2 is employed as a standard to prepare a calibration curve, based on which the ST2 in a sample is quantified.
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Abstract 2P-1005, entitled “Detection and Quantitation of human ST2 protein by using ST2 monoclonal antibodies,” in Program and Abstracts of the 22ndAnnual Meeting of the Molecular Biology Society of Japan (Meeting held Dec. 7-10, 1999). Program and Abstracts published on Nov. 22, 1999. with English translations of title page and Abstract 2P-1005.
English abstract and material from talk “Detection and Quantitation of human St2 protein by using ST2 monoclonal antibodies,” presented at the 22ndAnnual Metting of the Molecular Biology Society of Japan (Meeting held Dec. 7-10, 1999), presented on Dec. 9, 1999.
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Arai Takao
Kuroiwa Kenji
Oshikawa Katsuhisa
Tominaga Shin-ichi
Arai Takao
Armstrong Kratz Quintos Hanson & Brooks, LLP
Grun James L.
Le Long V.
Medical & Biological Laboratories Co. Ltd.
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