Monoclonal antibody and hybridoma producing the same

Details Monoclonal antibody and hybridoma producing the same Monoclonal antibody and hybridoma producing the same

2004-03-15

2008-10-14

Blanchard, David J. (Department: 1643)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Animal cell, per se, expressing immunoglobulin, antibody, or...

C424S138100, C424S141100

Reexamination Certificate

active

07435590

ABSTRACT:
The present invention establishes a simple and a highly sensitive detection method for hEPR and provides a novel detection method for human tumors which express hEPR. In particular, the present invention provides a monoclonal antibody which specifically recognizes human epiregulin (hEPR), hybridoma which produces the monoclonal antibody, and a highly sensitive detection method for hEPR using the monoclonal antibody.

REFERENCES:
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patent: 2002/0040127 (2002-04-01), Jiang et al.
patent: 2001-149079 (2001-06-01), None
patent: WO 01/62918 (2001-08-01), None
patent: WO 01/96390 (2001-12-01), None
patent: WO 03/057160 (2003-07-01), None
H. Toyoda et al., “Distribution of mRNA for human epiregulin a differentially expressed member of the epidermal growth factor family”,Biochemical Journal, vol. 326, part 1, Aug. 15, 1997, pp. 69 to 75.
Komurasaki T, “Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4”, Oncogene, 15, (23): Dec. 4, 1997, pp. 2841-2848.
Yuji Shirakata, et al., “Epiregulin, a Novel Member of the Epidermal Growth Factor Family, Is an Autocrine Growth Factor in Normal Human Keratinocytes”, The Journal of Biological Chemistry, 2000, 275(8):5748-5733.
Toshi Komurasaki, et al., “Mechanism of Growth Promoting Activity of Epiregulin in Primary Cultures of Rat Hepatocytes”, Growth Factors, 2002, 20(2):61-69.

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