Monoclonal antibody and assay for detecting PIIINP

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C530S388240, C530S388250

Reexamination Certificate

active

07541149

ABSTRACT:
The present invention relates to monoclonal antibodies binding to the N-terminal procollagen (III) propeptide (PIIINP) molecule which is a proteolytic fragment emanating from the specific cleavage of procollagen (III) by N-proteinase after exocytosis and to an assay using these antibodies.

REFERENCES:
patent: 4312853 (1982-01-01), Timpl
patent: 4504587 (1985-03-01), Timpl et al.
patent: 5434088 (1995-07-01), Ikeda et al.
patent: 5512283 (1996-04-01), Byers et al.
patent: 5679583 (1997-10-01), Brocks et al.
patent: (11) 63385 (1995-04-01), None
patent: 0004940 (1979-10-01), None
patent: 0289930 (1988-11-01), None
patent: 0298210 (1989-01-01), None
patent: 0304292 (1989-02-01), None
patent: 0339443 (1989-11-01), None
GenBank accession No. P02461, May 1, 2007, pp. 1-26.
Lotterer et al. New test for the determination of aminoterminal procollagen-III-peptide in serum using monoclonal antibodies. Journal of Hepatology, 1993, 18(suppl 1):S141, Abstract T-254.
Xie et al. Production and preliminary application of monoclonal antibodies of Type III procollagen. Mianyixue Zazhi (1994), 10(1), abstract.
Brocks, D. G., Steinert, C., Gerl, M., Knolle, J., Neubauer, H. P., and Gunzler, V., “A Radioimmunoassay for the N-terminal Propeptide of Rat Procollagen Type III”, Matrix, 13:381-387 (1993).
Bulleid, N. J., Wilson, R., and Lees, J. F., “Type-III Procollagen Assembly in Semi-intact Cells: Chain Association, Nucleation and Triple-Helix Folding do not Require Formation of Inter-Chain Disulphide Bonds but Triple-Helix Nucleation Does Require Hydroxylation”, Biochem. J., 317: 195-202 (1996).
Colige, A., Li, S. W., Sieron, A. L., Nusgens, B. V., Prockop, D. J., and Lapiere, “cDNA Cloning and Expression of Bovine Procollagen I N-Proteinase: A New Member of the Superfamily of Zinc-Metalloproteinases with Binding Sites for Cells and Other Matrix Components”, Proc. Natl. Acad. Sci. USA, 94: 2374-2379 (Mar. 1997).
Davies, B. H., and Madri, J. A., “An Immunohistochemical and Serum ELISA Study of Type I and III Procollagen Aminopropeptides in Primary Biliary Cirrhosis”, Am. J. Pathol., 128(2): 265-275 (1987).
Eriksen, E. F., Charles, P., Melsen, F., Mosekilde, L., Risteli, L., and Risteli, J., “Serum Markers of Type I Collagen Formation and Degradation in Metabolic Bone Disease: Correlation with Bone Histomorphometry”, Journal of Bone and Mineral Research, 8(2): 127-132 (1993).
Fleischmajer, R., Timpl, R., Tuderman, L., Raisher, L., Wiestner, M., Perlish, J. S., and Graves, P. N., “Ultrastructural Identification of Extension Aminopropeptides of Type I and III Collagens in Human Skin”, Proc. Natl. Acad. Sci. USA, 78(2): 7360-7364 (1981).
Hansen, M., Stoltengerg, M., Host, N. B., Boesby, S., Lorenzen, I., and Bentsen, K. D., “Glucocorticoids Inhibit the Synthesis Rate of Type III Collagen, but do not Affect the Hepatic Clearance of its Aminoterminal Propeptide (PIIINP)”, Scand. J. Clin. Lab. Invest., 55: 543-548 (1995).
Hayasaka, A., Koch, J., Schuppan D., Maddrey, W. C., and Hahn, E. G., “The Serum Concentrations of the Aminoterminal Propeptide of Procollagen Type III and the Hepatic Content of mRNA for the α1 Chain of Procollagen Type III in Carbon Tetrachloride-induced Rat Liver Fibrosis”, Journal of Hepatology, 13: 328-338 (1991).
Huse, W. D., Sastry, L., Iverson, S. A., Kang, A. S., Alting-Mees, M., Burton, D. R., Benkovic, S. J., and Lerner, R. A., “Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda”, Science, 246: 1275-1281 (1989).
Jeffers, L. J., Coelho-Little, E., Cheinquer, H., Vargas, C., Civantos, F., Alvarez, L., Reddy, K. R., Parker, T., De Medina, M., Li, X., Hill, M., LaRue, S., and Schliff, E. R., “Procollagen-III Peptide and Chronic Viral C Hepatitis”, Am. J. Gastroenterology, 90(9): 1437-1440 (1995).
Kuhn, K., Wiestner, M., Krieg, T., and Muller, P. K., “Structure and Function of the Amino Terminal Propeptide of Type I and III Collagen”, Connective Tissue Research, 10: 43-50 (1992).
Lee, S.-T., Kessler, E., and Greenspan, D. S., “Analysis of Site-Directed Mutations in Human Pro-α2(1) Collagen Which Block Cleavage by the C-Proteinase”, J. Biol. Chem., 265(35): 21992-21996 (1990).
Lees, J. F., and Bulleid, N. J., “The Role of Cysteine Residues in the Folding and Association of the COOH-Terminal Propeptide of Types I and III Procollagen”, J. Biol. Chem., 269(39): 24354-24360 (1994).
Moore, G. E. , Gerner, R. E., and Franklin, H. A., “Culture of Normal Leukocytes”, JAMA, 199(8): 87-92 (1967).
Murawaki, Y., Ikuta, Y., Nishimura, Y., Koda, M., and Kawasaki, H., “Serum Markers for Connective Tissue Turnover in Patients with Chronic Hepatitis B and Chronic Hepatitis C: A Comparative Analysis”, Journal of Hepatology, 23: 145-152 (1995).
Niemela, O., Risteli, L., Sotaniemi, E. A., and Risteli, J., “Heterogeneity of the Antigens Related to the Aminoterminal Propeptide ofType III Procollagen in Human Serum”, Clinica Chimica Acta, 124: 39-44 (1982).
Peltonen, L., Halila, R., and Ryhanen, L., “Enzymes Converting Procollagens to Collagens”, Journal of Cellular Biochemistry, 28: 15-21 (1985).
Plebani, M., and Burlina, A., “Biochemical Markers of Hepatic Fibrosis”, Clin. Biochem., 24: 219-239 (1991).
Rohde, H., Bruckner, P., and Timpl, R., “Immunochemical Properties of the Aminopropeptide of Procollagen Type III”, Eur. J. Biochem., 135: 197-202 (1983).
Rohde, H., Vargas, L., Hahn, E., Kalbfleisch, H., Brugera, M., and Timpl, R., “Radioimmunoassay for Type III Procollagen Peptide and its Application to Human Liver Disease”, European Journal of Clinical Investigation, 9: 451-459 (1979).
Savolainen, E.-R., Goldberg, B., Leo, M. A., Velez, M., and Lieber, C. S., “Diagnostic Value of Serum Procollagen Peptide Measurements in Alcoholic Liver Disease”, Alcoholism: Clinical and Experimental Research, 8(4): 384-389 (1984).
Schuppan, D., “Connective Tissue Polypeptides in Serum as Parameters to Monitor Antifibrotic Treatment in Hepatic Fibrogenesis”, Journal of Hepatology, 13(3): S17-S25 (1991).
Scott, I. C., Halila, R., Jenkins, J. M., Mehan, S., Apostolou, S., Winqvist, R., Callen, D. F., Prockop, D. J., Peltonen, L., Kadler, K. E., “Molecular Cloning, Expression and Chromosomal Localization of a Human Gene Encoding a 33 kDa Putative Metallopeptidase (PRSM1)”, Gene, 174: 135-143 (1996).
Uitto, J., Murray, L. W., Blumberg, B., and Shamban, A., “Biochemistry of Collagen Diseases”, Annals of Internal Medicine, 105: 740-756 (1986).
Ristell, J., Nieml, S., Trivedl, P., Mäentausta, O., Mowat, A. P., and Ristell, L., “Rapid Equilibrium Radioimmunoassay for the Amino-Terminal Propeptide of Human Type III Procollagen”, Clin. Chem., 34(1): 715:718 (1988).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Monoclonal antibody and assay for detecting PIIINP does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Monoclonal antibody and assay for detecting PIIINP, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibody and assay for detecting PIIINP will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4095174

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.