Monoclonal antibody and antibody components elicited to a polype

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide

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4351885, 5303889, C12P 2106, C12N 900, C07K 1528

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active

053188977

ABSTRACT:
What is disclosed is a catalytic monoclonal antibody able to cleave a polypeptide and in particular, a catalytic monoclonal antibody elicited by a ground state antigen is disclosed. Antigens include, among others, the polypeptide, a derivative of the polypeptide, a fragment of the polypeptide or any of these bound to a carrier molecule. Methods of making and using the catalytic monoclonal antibody are also disclosed.

REFERENCES:
patent: 4196265 (1980-04-01), Koprowski et al.
patent: 4376110 (1983-03-01), David et al.
patent: 4492751 (1985-01-01), Boguslaski et al.
patent: 4493890 (1985-01-01), Morris
patent: 4659567 (1987-04-01), Tramontano et al.
patent: 4792446 (1988-12-01), Kim et al.
patent: 4888281 (1989-12-01), Schochetman et al.
patent: 4900674 (1990-02-01), Benkovic et al.
Paul, S. et al. (1992) J. Biol. Chem. 267 (19), 13142-13145.
"Abzylutely Spot On", The Economist, 80-81 (Feb. 7, 1987).
"Abzymes", Scientific American, 256, No. 2, 84-85 (1987).
Affinity Chromatography Principles and Methods, Pharmacia, pp. 12-18, Uppsala Sweden (1986).
Altschuh, D. et al., "Localization of Antigenic Determinants of a Viral Protein by Inhibition of Enzyme-Linked Immunosorbent Assay (ELISA) with Tryptic Peptides", J. Immunology Methods, v. 50, p. 99 (1982).
Amit, A. G. et al., "Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 A Resolution", Science 233: 747 (1986).
Amzel, L. M. et al., "Three-Dimensional Structure of Immunoglobulins", Ann. Rev. Biochem. 48:961 (1979).
Anglister, J. et al., "NMR study of the Complexes Between a Synthetic Peptide Derived from the B Subunit of Cholera Toxin and Three Monoclonal Antibodies Against It", Abstract, American Chemical Soc. (1988), 006-2960/88/0427-0717.
"Antibody Catalyzes Stereospecific Reaction", Science/Technology Concentrates, C&EN, 15 (Aug. 31, 1987).
Aruffo, A. et al., "Molecular Cloning of a CD38 cDNA by a high-efficiency COS cell expression system", Proc. Natl. Acad. Sci., 84:8573-8577 (1987).
Atassi, M. Z., "Surface-Simulation Synthesis and Its Application in Protein Molecular Recognition", Protein Engineering-Application in Science, Medical and Industry, pp. 125-153 Edited by Inouye, M. and Sarma, R., Academic Press (1986).
Azuma, T. et al., "Diversity of the Variable-Joining Region Boudary of .lambda. Light Chains has a Pronounced Effect on Immunoglobulin Ligand-Binding Activity", Proc. Natl. Acad. Sci. USA, v. 81, p. 6139, (Oct. 1984).
Baldwin E. and Schuyltz, P. G., Generation of a catalytic antibody by site-directed mutagenesis. Science, 245, 1104-1107 (1989).
Barrett, A. J., Proteinase Inhibitors (Editors A. J. Barrett and G. Salvesen), pp. 3-22, Elsevier, London, (1986).
Baum, R., "Catalytic Antibody Cuts Peptide Bond", C & E N, 5, 7-8 (1989).
Baum, R., "Catalytic Antibodies Open Up New Strategy For Protein Engineering", Science, C&EN, 30-33 (April 6.
Benjamini, E. et al., "Immunochemical Studies on the Tobacco Mosaic Virus Protein. VI Characterization of Antibody Population Following Immunization with TMV Protein", Biochemistry, v.7, No. 4, pp. 1253-1260 (1968).
Benjamini, E. et al., "Immunochemical Studies on the Tobacco Mosaic Virus Protein. VII. The Binding of Octanoylated Peptides of the TMV Protein with Antibodies to the Whole Protein", Biochemistry, v.7, No. 4, pp. 1261-1264 (1968).
Berchtold et al., Blood, vol. 74, No. 7, pp. 2414-2417 (1989).
Better, M. et al., "Escherichia Coli Secretion of an Active Chimeric Antibody Fragment", Science, 240: 1041-1043 (1988).
Blackburn, G. M. et al., "Catalytic Antibodies", Biochem. J. 262: 381 (1989).
Bloom, S. R. et al., "Autoimunity in Diabetics Induced by Hormonal Contaminants of Insulin", Lancet i:14-17 (1979).
Brown, G. and Ling, N. R. Murine Monoclonal Antibodies. In Antibodies: A Practical Approach (Ed"D. Cathy) IRL Press, Oxford, U.K. vol. 1, pp. 81-104 (1988).
Bulletin Office Of Public Information, Berkeley Campus, University of California (Dec. 9, 1986).
Burd, J. et al., "Specific Protein-Binding Reactions Monitored by Enzymatic Hydrolysis of Ligands-Fluorescent Dye Conjugates", Analytical Biochemistry, 77, 56-67 (1977).
"Cancer Breakthrough Seen-IGEN Discovers New Protein Class", Rockville Gazette (Jan. 21, 1987).
Chalufour, A. et al., "Rare Sequence Motifs are Common Constituents of Hypervariable Antibody Regions", Ann. Inst. Pasteur/Immunology, 138:671, Elsevier, Paris (1987).
Chaudhary, V. J. et al., "A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin", Nature 339: 394 (1989).
Chothia, C. et al., "Canonical Structures for the Hypervariable Regions of Immuonoglobulins", J. Mol. Biol. 196: 901 (1987).
Chothia, C. et al., "The Predicted Structure of Immunoglobulin D1.3 and Its Comparison with the Crystal Structure", Reports, 755 (Aug. 1986).
Cochran, A. G. et al., "Photosensitized Cleavage of a Thymine Dimer by an Antibody", J. Am. Chem. Soc., 110: 7888-7890 (1988).
Colman, P. M. et al., "Three-Dimensional Structure of a Complex of Antibody with Influenza Virus Neuraminidase", Nature 326: 358 (Mar. 1987).
Corey, D. R. et al., "Generation of a Hybrid Sequence-Specific Single-Stranded Deoxyribonuclease", Reports 1401 (Dec. 1987).
Creighton, T. E. Disulfide bonds between cystein residues. In Protein Structure: A Practical Approach (Ed. T. E. Creighton) IRL Press, Oxford, U.K., pp. 155-167.
David, G. S. et al., "The Hybridoma-An Immunochemical Laser", Clin, Chem., 27 (9), 1580-1585 (1981).
Davies, D. R., Padlan, E. A. and Sheriff, S.: Antibody-antigen complexes. Ann. Rev. Biochem., 59, 439-474 (1990).
de la Paz, P. et al., "Modelling of the Combining Sites of Three-Anti-Lysozyme Monoclonal Antibodies and of the Complex Between One of the Antibodies and its Epitope", EMBO J., 5:2, 415 (1986).
Dimaline, R. et al., "A novel VIP from elasmobranch intestine has full affinity for mammalian pancreatic VIP receptors", Biochimica et Biophysica Acta, 930, 97-100 (1987).
Dimaline, R. et al., "Purification and Characterization of VIP from Two Species of Dogfish", Peptides, 7 (Suppl. 1): 21-26 (1986).
Dixon, M. et al., Enzymes, Third Edition, London, (1979).
Durfor, C. N. et al., "Antibody Catalysis in Reverse Micelles", J. Am. Chem. Soc. 110, 8713 (1988).
Edelman, G. M. et al., "Reconstitution of Immunologic Activity by Interaction of Polypeptide Chains of Antibodies", Proc. Natl. Acad. Sci., 50: 753-761 (1963).
Emr, S. D. et al., "Sequence analysis of mutations that prevent export of .lambda. receptor, an Escherichia coli outer membrane protein", Nature, 285: 82-85 (1980).
Erhan, S. et al., "Do immunoglobulins have proteolytic activity?", Nature, v.251, pp. 353-355 (Sep. 27, 1974).
Fisher, G., "Acyl Group Transfer-Aspartic Proteinases", Enzyme Mechanisms (Editors: M. I. Page and A. Williams), Royal Society of Chemistry, London, 230 (1987).
FPLC.TM. Ion Exchange and Chromatofocusing-Principles and Methods, Pharmacia, pp. 59-106, Uppsala, Sweden (1987).
Frackelton, Jr., A. R., et al., "Functional Diversity of Antibodies Elicted by Bacterial .beta.-D Galactosidase", J. Bio. Chem., 255 (11), 5286-5290 (1980).
Franek, F. and Wezlin, R. S., Biokhimiya, 28: 193 (1963).
Franek, F. and Nezlin, R. S., "Recovery of Antibody Combining Activity By Interaction of Different Peptide Chains Isolated from Purified Horse Antitoxins", Folia Microbiol., 8: 128-130 (1963).
French, D. L., R. Laskow, and M. D. Scharff. The role of somatic hypermutation in the generation of antibody diversity. Science 244, 1152 (1989).
Gavish, M. et al., "Preparation of a Semisynthetic Antibody", Abstract, Am. Chem. Soc. (1978), 006-2960/78/0417-1345.
Geysen, H. M. et al., "A Priori Delineation of a Peptide Which Mimics a Discontinous Antigenic Determinant", Molecular Immunology, 23:7 p. 709 (1986).
Giam, C. Z. et al., "In Vivo and In Vitro Autoprocessing of Human Immunodeficiency Virus Protease Expressed in Escherichia Coli", J. Biol. Chem., 263: 14617-14620 (1985).
Gish et al., J. Med Chem., 14: 1159-1162, (1971).
Hansen, D., "Antibodies with Some Bite", Nature, 325, 304 1987).
Harper, J. W. et al., "Enzymatically Active Angiogenin/Ribonunclease A Hybrids Form

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