Monoclonal antibody against human hepatoma and use thereof

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...

Reexamination Certificate

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C530S387100, C530S388100, C530S391700, C424S141100

Reexamination Certificate

active

10544036

ABSTRACT:
The present invention provides a monoclonal antibody MF4C4 against human hepatoma marker antigen. This monoclonal antibody is characterized by high specifically binding to the hepatoma antigen. The present invention also provides MF4C4 immunoglobulins, and the fragments and immunological conjugates thereof, and pharmaceutical compositions containing the immunoglobulins, fragments or immunological conjugates. The invention further provides a kit for detecting hepatoma.

REFERENCES:
patent: 2002/0090627 (2002-07-01), Meyers
patent: 2005/0233392 (2005-10-01), Filmus et al.
patent: WO 91/09045 (1991-06-01), None
patent: WO 9937764 (1999-07-01), None
patent: WO 01/75121 (2001-10-01), None
Jones (Pharmacogenomics Journal, 1:126-134, 2001).
Tosatto et al, (Current Pharmaceutical Design, 12:2067-2086, 2006).
Fundamental Immunology (William E. Paul, M.D. ed., 3d ed; p. 242, 1993).
Lage et al (Virchows Arch. 438:567-573, 2001).
Elgert et al. Immunology: Understanding the Immune System, 1996, p. 59.
Hsu et al (Cancer Research, 57(22):5179-5184, 1997).

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