Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-07-26
1997-08-12
Green, Lora M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436501, 436547, 436548, 436817, 436161, 53038824, 5303889, 5303892, 5303898, G01N 3353
Patent
active
056564341
ABSTRACT:
The present invention provides monoclonal antibodies that specifically recognize a specific structural portion of cardiac glycoside.
The monoclonal antibodies of the present invention recognize an integrated structure in the steroid structure of cardiac glycoside or its aglycon comprising: a D-ring bonded in the cis-configuration with respect a C-ring; a methyl group bonded in the .beta.-configuration at the C13 position; a hydroxyl group bonded in the .beta.-configuration at the C14 position; and, an .alpha., .beta.-unsaturated lactone group bonded in the .beta.-configuration at the C17 position. This structure is common to cardiac glycoside substances that inhibit potassium ion concentration antagonist type Na.sup.+,K.sup.+ -ATPase.
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Nakazato Hiroshi
Terano Yoshitake
Green Lora M.
Suntory Limited
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