Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1993-03-04
1995-08-01
Lacey, David L.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
53038824, C12N 512, C07K 1622
Patent
active
054379954
ABSTRACT:
The present invention provides a hybrid cell line producing monoclonal antibody to an acidic fibroblast growth factor (aFGF) protein. The hybridoma is established by fusing spleen cells from immunized mice with myeloma cells. The hybridomas are cultured as clones, and antibodies obtained from the individual clones are tested for their specificity for aFGF protein. Antibodies can be obtained from the culture growth medium or from ascitic fluid of mice bearing the hybridoma tumor. Diagnostic and therapeutic uses of the monoclonal antibody are also disclosed.
REFERENCES:
patent: 5187062 (1993-02-01), Sato et al.
Ichimori, Y. et al, Biochem Biophys Res Com, 175(1):291-297, Feb. 28, 1991.
Burgess et al., J. Cell Biol, 111:2129-2138, Nov. 1990.
Masogolia, S. L. et al., J Cell Physiol, 132:531-537, 1987.
Riss, et al., Journal of Cellular Physiology, 138:405-414 (1989).
The 27th Meeting: The Radioimmunoassay Research Society of Japan; Nov. 26, 1988-and English Translation.
The 62nd Meeting: The Japanese Endocrine Society, Jun. 1, 1990-and English Translation.
Ichimori Yuzo
Igarashi Koichi
Kondo Koichi
Sendo Masaharu
Conlin David G.
Lacey David L.
Loring Susan A.
Resnick David S.
Takeda Chemical Industries Ltd.
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