Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-03-28
1999-08-31
Housel, James C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435 792, 435 794, 435 795, 435 7021, 4351722, 435336, 436518, 436536, 436548, 53038824, 530413, 935104, 935108, 935110, G01N 3353, G01N 3374, C07K 1626
Patent
active
059452960
ABSTRACT:
The invention relates to monoclonal antibody capable of specific binding to the molecular weight of 20 kDa variant of human growth hormone. This monoclonal antibody has no substantial binding to hGH of molecular weight 22 kDa. The invention also relates to the use of this monoclonal antibody for measurement of hGH 20K, especially in body fluids. The antibodies can be used for detection and quantification of hGH 20K, especially in serum.
REFERENCES:
patent: 5496713 (1996-03-01), Honjo et al.
Mazza et al., 1990. Relationship between the antigenic topography and the structure of human growth hormone. Endocrinol. 127: 1002-1008.
Hellstrom et al., 1985. in Monoclonal Antibodies for Cancer Detection and Therapy (Baldwin et al., eds), Academic Press, London, p. 20.
Mellado et al., Apr. 1996, Characterization of monoclonal antibodies specific for the human growth hormone 22K and 20K isoforms, J Clin Endocrinol. Metab. 81: 1613-1618.
Cunningham et al, Science, 234, 1989.
Hormone Research, Bo Dinesen, vol. 36, No. 1, 1991, 11-16.
Hormone Research, S. Woodhead et al., vol. 36, No. 1, 1991, 17-20.
Journal of Immunoassay, F. Gomez et al., vol. 5, 1984, 145-157.
Mat. Lib. of Medicine, Medline, No. 88228396. Abstract Only.
Mat. Lib. of Medicine, Medline, No. 85213514. Abstract Only.
Mat. Lib. of Medicine, Medline, No. 95157536. Abstract Only.
Alonso Carlos Martinez
Baron Leonor Kremer
Frade Jose Miguel Rodriguez
Garcia Jose Mario Mellado
Hansson Yngve Elof
Consejo Superior de Investigaciones
Grun James L.
Housel James C.
Pharmacia & UpJohn AB
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