Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using tissue cell culture to make a protein or polypeptide
Patent
1995-02-14
1998-07-28
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using tissue cell culture to make a protein or polypeptide
435331, 436547, 436548, 530327, 5303879, 5303881, 5303891, A61K 39395
Patent
active
057861803
ABSTRACT:
The instant invention provides for monoclonal antibody which is specific for the .beta.A4 peptide, and in particular the free C-terminus of .beta.A4 "1-42" but not "1-43", and stains diffuse and fibrillar amyloid, vascular amyloid, and neurofibrillary tangles. The instant invention further provides for antibody fragments and constructs thereof which have the same binding specificity. The instant invention also provides for methods of diagnosis, screening and therapeutics for treating unique forms of .beta.A4 peptide, using the antibodies of the instant invention.
REFERENCES:
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Master et al., "Amyloid plaque core protein in Alzheimer's disease and Down syndrome" PNAS (USA) 82: 4245-4249 (1985).
Miller et al., "Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease" Arch. Biochem. Biophys. 301: 41-52 (1993).
Suzuki et al., "An increased percentage of long amyloid B protein secreted by familial amyloid B protein precursor (BAPP.sub.717) mutants" Science 264:1336-1340 (1994).
Yang et al., "Monoclonal antibody to the C-terminus of B-amyloid" Neuro. Report 5: 2117-2120 (1994).
Murphy et al., "Development of a monoclonal antibody specific for the COOH-terminal of B-amyloid 1-42 and its immunohistochemical reactivity in Alzheimer's disease and related disorders" Am. J. Pathol. 144: 1082-1088 (1994).
Seubert et al., Nature 359: 325-327, Sep. 24, 1992.
Harlow et al., In Antibodies: A Laboratory Manual, Cold Spring Harbor Press Inc., 1988, pp. 72-87.
Iwatsubo et al., Neuron, 13: 45-53, Jul. 1994.
Hermanson et al., "Immobilized affinity Ligand Techniques", 1992, by Academic Press Inc., San Diego, CA. pp. 137-138 and 150-151.
Graham Paul
Konig Gerhard
Bayer Corporation
Duffy Patricia A.
Hutzell Paula K.
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