Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2005-03-31
2010-12-28
Gabel, Gailene R (Department: 1641)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S380000, C530S388100, C530S388200, C435S007200, C435S007250, C435S287200, C436S547000, C436S548000, C436S063000, C436S175000, C436S177000
Reexamination Certificate
active
07858757
ABSTRACT:
The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.
REFERENCES:
patent: 2003/0180762 (2003-09-01), Tuma et al.
patent: WO 02/101387 (2002-12-01), None
Alvarez et al. Development, Characterization, and Use of Monoclonal Antibodies Made to Antigens Expressed on the Surface of Fetal Nucleated Red Blood Cells, Clinical Chemistry 45 (9):1614-1620, (1999).
Bianchi et al. Erythroid-Specific Antibodies Enhance Detection of Fetal Nucleated Erythrocytes in Maternal Blood,Prenatal Diagnosis, 13: 293-300 (1993).
Alvarerz et al., “Development, characterization, and use of monoclonal antibodies made to antigens expressed on the surface of fetal nucleated red blood cells,”Clin. Chem., 45:1614-1620, 1999.
Bianchi et al., “Erythroid-Specific Antibodies Enhance Detection of Fetal Nucleated Erythrocytes in Maternal Blood,”Prenatal Diagnosis, 13:293-300, 1993.
Bianchi et al., “Fetal Cells in the maternal circulation: feasibility for prenatal diagnosis,”Br. J. Haematology, 105:574-583, 1999.
Huie et al., “Antibodies to human fetal erythroid cells from a nonimmune phage antibody library,”Proc. Natl. Acad. Sci. USA, 98:2682-2687, 2001.
Albert Winfried
Hollmann Christiane
Stachelhaus Stefan
Zimmermann Silke
Adnagen AG
Fulbright & Jaworski
Gabel Gailene R
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