Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1989-01-04
1991-09-10
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530388, 530389, 435 7021, 4351722, 43524027, 424 11, 935104, 935107, 935108, 935110, C07K 1528, C12P 2108, C12N 520, A61K 4300
Patent
active
050475070
ABSTRACT:
The invention concerns novel monoclonal antibodies with high specificity to and affinity for human carcinoembryonic antigen (CEA), derivatives thereof, processes for the preparation of these antibodies and their derivatives, hybridoma cell lines secreting the antibodies, and processes for the preparation of said cell lines. The monoclonal antibodies of the invention and their derivatives are useful in the diagnosis and therapy of cancer and serial monitoring of cancer patients for recurrent disease or response to therapy. Test kits and pharmaceutical compositions containing said monoclonal anti-CEA antibodies are also subject of the invention.
REFERENCES:
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Hedin, A., et al., International Journal of Cancer, 30:547-552, (1982).
Haskell, C. M., et al., Cancer Research, 43:3857-3864, (Aug. 1983).
Hedin, A., et al., Molecular Immunology, 23:1053-1061, (1986).
Buchegger, F., et al., International Journal of Cancer, 41:127-134, (1988).
Accolla et al., Proc. Natl. Acad. Sci. U.S.A., vol. 77, No. 1, pp. 563-566, Jan., 1980.
Mach et al., Immunology Today, 2, pp. 239-249, Dec., 1981.
Buchegger, et al., Immunology Letters, 5, 1982, pp. 85-91.
Buchegger, et al., J. Exp. Med., 158, pp. 413-427 (1983).
Buchegger, et al., Int. J. Cancer, 33, pp. 643-649 (1984).
Paxton, et al., Proc. Natl. Acad. Sci. U.S.A., vol. 84, pp. 920-924, Feb., 1987.
Buchegger Franz
Mach Jean-Pierre
Budens Robert D.
Moskowitz Margaret
Research Corporation Technologies Inc.
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