Monoclonal antibodies which specifically binds to endosialin, a

Details Monoclonal antibodies which specifically binds to endosialin, a Monoclonal antibodies which specifically binds to endosialin, a

1992-11-13

1994-08-30

Lacey, David L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 723, 43524027, 5303877, 5303911, G01N 33574, A61K 39395, C07K 1528

Patent

active

053427572

ABSTRACT:
The invention involves monoclonal antibodies which specifically bind to a cell surface antigen characteristic of tumor vascular endothelium. The antigen, referred to as endosialin, is a glycoprotein and has a molecular weight of about 165 kDa as determined by SDS-PAGE. The protein portion of the molecule has a molecular weight of about 95 kDa. Also disclosed are various uses of the monoclonal antibody and the antigen.

REFERENCES:
Harris et al. TIBTECH 11: 42-44 (1993).
Rettig et al. PNAS 89: 10832-10836 (1992).
Ruiter et al. J. Invest. Dermatol 93: 255-325 (1989).
Schlingemann et al. Am. J. Pathol. 138: 1335-1347 (1991).
Dillman Annals Int. Med 111: 592-603 (1989).
Garin-Chesa et al. PNAS 87: 7235-7239 (1990).

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