Monoclonal antibodies which neutralize HIV-1 through reaction wi

Details Monoclonal antibodies which neutralize HIV-1 through reaction wi Monoclonal antibodies which neutralize HIV-1 through reaction wi

1991-04-26

1993-09-14

Lacey, David L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303894, 530809, 530866, 5303883, 530 2353, 435 696, 43524027, 4351722, 424 858, 424 86, 935 15, 935 95, A61K 3921, C12N 1512, C12N 520

Patent

active

052450155

ABSTRACT:
The monoclonal antibodies (mAbs) of the invention bind to a neutralizing epitope on the gp120 glycoprotein of HIV-1. The binding seems to be conformation-dependent, in the sense that altering the conformation of gp120 (by deglycosylating the gp120, by reducing the cysteine bonds in the peptide backbone) will inhibit the binding. The mAbs of the invention are group specific and can neutralize different strains and different isolates of HIV-1. The binding of these mAbs to gp120 is enhanced by the binding of other antibodies to the principal neutralizing determinant (amino acid residue numbers 296-331) of gp120.

REFERENCES:
patent: 4772547 (1988-09-01), Heimer
Robinson et al. AIDS Research and Hum. Retro. 6(5): 567-579 (May 1990) "Id. of Cons. and Variant Epit. of HIV-1 gp. 120 by Human Malo prod. by EBV trans. cell lines".
Posner et al., J. of Imm., 146:4325-4333, (May 16, 1991) "An IgG Hum. Mab that reacts w/HIV-1/gp 120, inhib. virus binding, and neutralizes infection".
Fung et al., J. of Virology 66(2):848-856 (1992).
Ho et al., PNAS 88:8949-8952 (1991).
Lerner et al., Advances in Immunology 36:1-44 (1984) Antibodies of Predetermined Specificity in Biology and Medicine.

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