Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1992-09-22
1998-12-29
Eisenschenk, Frank C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038835, 5303894, 4353391, C07K 1600, C12N 518
Patent
active
058544003
ABSTRACT:
Murine monoclonal antibodies and related products such as antibody fragments, immunotoxins, human and humanized antibodies are disclosed, all of which bind to the gp120 protein on the envelope of HIV-1. These antibodies and related products neutralize HIV-1. They inhibit the infection of T cells, and also inhibit syncytium formation. Further, the antibodies are preferably group-specific and neutralize various strains and isolates of HIV-1. These antibodies have a variety of uses, including the treatment of AIDS and ARC, the prevention of HIV-1 infection, as well as a diagnostic application, in that they can be used for assaying of unknown fluid samples for HIV-1.
REFERENCES:
"Restricted Neutralization of Divergent Human T-Lymphotropic Virus Type III Isolates by Antibodies to the Major Envelope Glycoprotein," 83 Proc. Natl. Acad. Sci. USA 9709-9713 (1986); Mathews et al.
Prospect for Prevention of Human Immunodeficiency Virus Infection: Purified 120-K Da Envelope Glycoprotein Induces Neutralizing Antibody, 83 Proc. Natl. Acad. Sci. USA 7023-7027 (1986); Robev et al.
"HTLV-III-Neutralizing Antibodies in Patients With AIDS and AIDS-Related Complex," 316 Nature 72-74 (1985); M. Robert-Guroff , et al.
"Infection of HTLV-III LAV in HTLV-1-Carrying Cells MT-2 and MT-4 and Application in a Plaque Assay," 229 Science 563-566 (1985); S. Harada , et al.
"Neutralization of the AIDS Retrovirus by Antibodies. to a Recombinant Envelope Glycoprotein," 233 Science 209-212 (1986); L.A. Lasky, et al.
"HTLV-III-Neutralizing Antibodies to an E. Coli-Produced Fragment of the Virus Envelope," 234 Science 1392-1395 (1986); S.D. Putney et al.
"AIDS Virus ENV Protein Expressed From a Recombinant Vaccinia Virus," 4 Bio/Technology 790-795 (1986); M.P. Kieny et al.
"The CD4 (T4) Antigen is an Essential Component of the Receptor for the AIDS Retrovirus," 312 Nature 763-67 (1984); Dagleish et al.
"Induction of CD4-Dependent Cell Fusion by the HTLV-III/LAV Envelope Glycomprotein," 323 Nature 725-728 (1986); Lifson et al.
"Role of the HTLV-III/LAV Envelope in Syncytium Formation and Cytopathicity," 322 Nature 470-474 (1986); Sodroski et al.
"Binding of HTLV-III/LAV to T4+T Cells by a Complex of the 110k Viral Protein and the T4 Molecule," 232 Science 382-385 (1986); J.S. McDougal et al.
"Neutralization of Human T-Lymphotropic Virus Type III by Sera of AIDA and AIDS-Risk Patients," 316 Nature 69-72 (1985); Weiss et al.
"Neutralization of HTLV-III/LAV Replication by Antiserum to Thymosin alpha.sub.1," 232 Science 1135-1137 (1986); Sarin et al.
"Human Immunodeficiency Virus Contains an Epitope Immunoreactive with Thymosin Alpha.sub.1 and the 30-Amino and Synthetic p17 Group-Specific Antigens Peptide HGP-30," 84 Proc. Natl. Acad. Sci. USA 2951-55 (1987); P.H. Naylor, et al.
"Expression of the Fusion Protein of Human Respiratory Syncytial Virus from Recombinant Vaccinia Virus Vectors and Protection of Vaccinated Mice," vol. 61, No. 2 Journal of Virology 293-301 (1987); G.W. Wertz et al.
"Expression of the HTLV-III Envelope Gene by a Rocombinant Vaccinia Virus," 320 Nature 535-540 (1986); S. Chakrabarti et al.
"T-Lymphocyte Priming and Protection Against Friend Leukemia by Vaccinia-Retrovirus env Gene Recombinant," 234 Science 728-731 (1986); P.L. Earl, et al.
"The First Human Retrovirus," vol. 254 No. 12 Scientific American 88-98 R.C. Gallo.
"A Chemical Technique for the Preparation of Bispecific Antibodies from Fab' Fragments of Mouse Mobnoclonal IgG.sub.1," vol. 4 No 5 Biotechniques 424-427 (1986) M. Brennan.
"Chimeric Antibodies with 17-1A-Derived Variable and Human Constant Regions," 5 Hybridoma Suppl. 1 (1986) ; L.K. Sun et al.
"Transfectomas Provide Novel Chimeric Antibodies," 229 Science 1202-07 (1985); S.L. Morrison.
"Chimeric Antibodies," vol. 4 No. 3 Biotechinques 214-221 (1986); V.T. Oi & S.L. Morrison.
Chang Nancy T.
Chang Tse Wen
Fung Michael S. C.
Sun Bill N. C.
Sun Cecily R. Y.
Eisenschenk Frank C.
Mirabel Eric P.
Tanox, Inc.
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