Monoclonal antibodies which identify the glycoprotein carrying t

Details Monoclonal antibodies which identify the glycoprotein carrying t Monoclonal antibodies which identify the glycoprotein carrying t

1996-04-02

1999-11-02

Feisee, Lila

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 79, 435 792, 436 63, 436 64, 5303888, G01N 33574, G01N 3353, G01N 33542, G01N 3348

Patent

active

059768185

ABSTRACT:
Hybridomally produced monoclonal antibodies specifically immunoreactive with the glycoprotein carrying the CA 125 epitope. Monoclonal antibodies recognize both high and low molecular weight subunits of the antigen, and identify the antigen in the cytoplasm and the extracellular matrix of CA 125 producing cells. An immunoassay for the detection of CA 125 utilizing the monoclonal antibodies is described.

REFERENCES:
patent: 4921790 (1990-05-01), O'Brien
patent: 5059680 (1991-10-01), Davis et al.
Hardardottir, H., et al., "Distribution of CA 125 in embryonic tissues and adult derivatives of the fetal periderm," Am J Obstet Gynecol, vol. 163, pp. 1925-1931, 1990.
Baldwin, et al, Monoclonal Antibodies for Cancer Determination and Therapy, p. 20, 1985.
Kohler & Milstein, Nature, vol. 256, pp. 495-497, Aug. 7, 1975.
Hardardottir, H, et al., Am J Obstet Gynecol, 163 (6 Pt 1) pp. 1925-1931, Dec. 1990 (Abstract Only).
Davis, HM, et al, Cancer Res, vol. 46, pp. 6143-6148, Dec. 1986.
Endo et al, "Development of a New Sensitive Immunoradiometric Assay for CA 125: Mixed use of two monoclonal antibodies reactive with separate epitopes" J of Tumor Marker Oncology, vol. 3, No. 1, pp. 65-71, 1988.

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