Monoclonal antibodies which bind to tumor rejection antigen prec

Details Monoclonal antibodies which bind to tumor rejection antigen prec Monoclonal antibodies which bind to tumor rejection antigen prec

1996-03-26

1997-10-07

Caputa, Anthony C.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Animal cell, per se, expressing immunoglobulin, antibody, or...

5303881, 53038885, C12N 512, C07K 1600, C12P 2108

Patent

active

056747497

ABSTRACT:
The invention relates to monoclonal antibodies which specifically bind to the tumor rejection antigen precursor molecule Melan-A, hybridomas which produce these monoclonal antibodies, and their use. Also described is a recombinant form of Melan-A and immunogenic compositions containing the molecules, and an adjuvant.

REFERENCES:
Coulie et al., "A New Gene Coding For A differentiation Antigen-Recognized By Autologous Cytolytic T Lymphocytes On HLA-A2 Melanomas," J. Exp. Med. 180: 35-42 (Jul. 1994).
Kawakami et al., "Indentification of the Immunodominant Peptides-of the Mart-1 Human Melanoma Antigen Recognized by the Majority of HLA-A2 Restricted Tumor Infiltrating Lymphocytes", J. Exp. Med. 180: 347-352 (Jul. 1994).
Chen et al., "Identification of the MAGE-1 Gene Product By -Monoclonal And Polyclonal Antibodies", Proc. Natl. Acad. Sci. USA 91: 1004-1008 (Feb. 1994).

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