Monoclonal antibodies which bind the gamma chain of human interl

Details Monoclonal antibodies which bind the gamma chain of human interl Monoclonal antibodies which bind the gamma chain of human interl

1994-04-21

1996-12-10

Feisee, Lila

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

53038822, 53038823, 5303881, 5303871, 43524027, A61K 39395, C07K 1628, C07K 1624, C12N 512

Patent

active

055828264

ABSTRACT:
A polypeptide which specifically binds to the .gamma.-chain of the human interleukin-2 receptor and selectively inhibits the binding of the .gamma.-chain of human interleukin-2 receptor to the .beta.-chain of the same is provided. The polypeptide has an activity of blocking the human interleukin-2 response. Also provided are an immunosuppressant containing the polypeptide, a DNA gene coding for the polypeptide, a recombinant DNA having the gene, a transformant having the recombinant DNA, and a method for producing the intended polypeptide by incubating the transformant. The novel polypeptide can be used independently, or with substances capable of inhibiting the binding of interleukin-2 to the interleukin-2 receptor, as a medicine for preventing the rejection of grafts after transplantation and also for curing inflammatory diseases such as allergic diseases and autoimmune diseases.

REFERENCES:
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 5084391 (1992-01-01), Wijdenes et al.
patent: 5317087 (1994-05-01), Cerreiti et al.
patent: 5352772 (1994-10-01), Smith
Waldmann, T. A., Science, 252:1657-1662, 21 Jun. 1991.
Harris, W. J. et al, TIBTECH, 11:42-44, Feb. 1993.
Winter, G. et al., TIPS, 14:139-143, May 1993.
Ishii, N. et al, International Immunology, 6(8):1273-1277, Aug. 1994.
Takeshita, T. et al., Science, 257:379-382, 17 Jul. 1992.

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