Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1991-09-06
1996-11-05
Budens, Robert D.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
4241451, 4241581, 4241981, 435 7021, 4351722, 53038823, 53038824, 5303892, 530399, C12N 520, C07K 1622, C12P 2108, A61K 39395
Patent
active
055717144
ABSTRACT:
Monoclonal antibodies have been produced which bind to Transforming Growth Factors .beta.1 (TGF-.beta.1) and .beta.2 (TGF-.beta.2). The monoclonal antibody produced by the hybridoma designated 1D11.16 deposited as A.T.C.C. Accession No. HB 9849 binds to both TGF-.beta.1 and TGF-.beta.2. The antibodies are produced by immunizing with TGF-.beta.2 and may be of any isotype. The antibodies may be of any mammalian origin such as murine or human origin. Diagnostic and therapeutic applications utilizing the monoclonal antibodies are also disclosed.
REFERENCES:
Lee et al; J. Exp. Med. 166;1290-1299, Nov. 1987.
Keski-Oja, Cancer Research 47:6451-6458, Dec. 15, 1987.
Flanders et al., Biochemistry 27:739-746, 1988.
Ellingsworth et al., Cellular Immunology 114:41-54, 1988.
Galfre et al., Method in Encymology 73:3-46, 1981.
Dasch et al., "Moanoclonal Antibodies Recognizing Transforming Growth Factor-.beta.: Bioactivity Neutralization and Transforming Growth Factor-.beta.2 Affinity Purification, " J. Immunol. 142(5):1536-1541, Mar. 1, 1989.
Dasch James R.
Pace, III Doran R.
Waegell Wendy O.
Budens Robert D.
Celtrix Pharmaceuticals Inc.
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