Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Patent
1995-05-04
1998-07-21
Budens, Robert D.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
4241451, 4241581, 5303873, 53038823, 53038824, 5303892, A61K 39395, C07K 1622
Patent
active
057831858
ABSTRACT:
Monoclonal antibodies to transforming growth factor beta (TGF-B) are prepared from hybrid cell lines by immunizing with TGF-B2. The antibodies may be of any isotype and may be of any mammalian origin such as murine or human origin. Therapeutic applications for treating or reducing the likelihood of developing acute or chronic fibrosis utilizing the TGF-B monoclonal antibody are also disclosed.
REFERENCES:
patent: 4774322 (1988-09-01), Seyedin et al.
Durum et al., "Proinflammatory Cytokines and Immunity," Fundamental Immunology, 3rd Ed., Paul, W.E. Ed. Raven Press, Ltd, New York, 1993.
Waegell et al., "Growth acceleration and stem cell expansion in Dexter-type cultures by naturalization of TGF-.beta." Experimental Hematology (1994) 22:1051-1057.
Roberts et al., "Type .beta. transforming growth factor: a bifunctional regulator of cellular growth" Proc. Natl. Acad. Sci. USA (1985) 82:119-123.
Hayashi et al., "Differential effects of TGF-.beta..sub.1 on lymphohemopoiesis in long-term bone marrow cultures" Blood (1989) 74(5):1711-1717.
Carlino et al., "Transforming growth factor .beta. 1 systematically modulated granuloid, erythroid, lymphoid, and thrombocytic cells in mice" Exp. Hematol. (1992) 20:943-950.
Han et al., "Megakaryocytopoiesis: characterization and regulation in normal and pathologic states" Int. J. Hematol. (1991) 54(1):3-14.
Ishibashi et al., "Type .beta. transforming growth factor is a potent inhibitor of murine megakaryocytopoiesis in vitro" Blood (1987) 69:1737-1741.
Keller et al., "Transforming growth factor .beta. directly regulates primitive murine hematopoietic cell proliferation" Blood (1990) 75:596-602.
Cashman et al., "Mechanisms that regulate the cell cycle of very primitive hematopoietic cells in long-term human marrow cultures. I. Stimulatory role of a variety of mesenchymal cell activators and inhibitory role of TGF-.beta." Blood (1990) 75(1):96-101.
Ellingsworth et al., "Antibodies to the N-terminal portion of cartilage-inducing factor A and transforming growth factor .beta." J. Biol. Chem. (1986) 261:12362-12367.
Eaves et al., "Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer" Blood (1991) 78(1):110-117.
Hatzfeld et al., "Release of early human hematopoietic progenitors form quiescence by antisense transforming growth factor .beta. 1 or Rb oligonucleotides" J . Exp. Med, (1991) 174:925-929.
Wang et al., "Expression cloning and characterization of the TGF-.beta. type III receptor" Cell (1991) 67:797-805.
Jordan et al., "Cellular and developmental properties of fetal hematopoietic stem cells" Cell (1990) 61:953-963.
Waegell et al., "Neutralizing antibody to TGF-.beta. overcomes normal growth controls in long-term bone marrow cultures" J. Cell. Biochem. (1992) 16:92 (abstract No. M342).
Dasch et al., "Monoclonal antibodies recognizing transforming growth factor-.beta.. Bioactivity neutralization and transforming growth factor .beta. 2 affinity purification" J. Immunol. (1989) 142:1536-1547.
Herlyn et al., "Growth-regulatory factors for normal, premalignant, and malignant human cells in vitro" Adv. Cancer. Res. (1990) 54:213-234.
Harris et al., "Therapeutic antibodies --the coming of age" TIBTECH (1993) 11:42-44.
Lucas et al., "The autocrine production of transforming growth factor-.beta..sub.1 during lymphocyte activation" J. Immunol. (1990) 145:1415-1422.
Galfre et al., "Preparation of monoclonal antibodies: strategies and procedures" Meth. Enzymol. (1981) 73:3-46.
Cheifetz et al., "The transforming growth factor-.beta. system: A complex pattern of cross-reactive ligands and receptors" Cell (1987) 48:409-416.
Ellingsworth et al., "Transforming growth factor-.beta. s are equipotent growth inhibitors of interleukin-1-induced thymocyte proliferation" Cell. Immunol. (1988) 114:41-54.
Kehrl et al., "Production of transforming growth factor-.beta. by human T lymphocytes and its potential role in the regulation of T cell growth" J. Exp. Med. (1986) 163:1037-1050.
Kehrl et al., "Transforming growth factor .beta. is an important immunomodulatory protein for human B lymphocytes" J. Immunol. (1986) 137:3855-3860.
Keller et al., "Transforming growth factor .beta.-1 selectively regulates early murine hematopoietic progenitors and inhibits the growth of IL-3-dependent myeloid leukemia cell lines" J. Exp. Med. (1988) 168:737-750.
Keski-Oja et al., "Immunodetection and modulation of cellular growth with antibodies against native transforming growth factor-.beta..sup.1" Cancer Res. (1987) 47:6451-6458.
Lee et al., ".beta. transforming growth are potential regulators of B lymphopoiesis" J. Exp. Med. (1987) 166:1290-1299.
Ohta et al., "Two forms of transforming growth factor-.beta. distinguished by multipotential hematopoietic progenitor cells" Nature (1987) 329:539-541.
Ranges et al., "Inhibition of cytotoxic T cell development by transforming growth factor .beta. and reversal by recombinant tumor necrosis factor alpha" J. Exp. Med. (1987) 166:991-998.
Rook et al., "Effects of transforming growth factor .beta. on the functions of natural killer cells depressed cytolytic activity and blunting of interferon responsiveness" J. Immunol. (1986) 136:3916-3920.
Rosa et al., "Mesoderm induction in amphibians the role of TGF-.beta.-2-like factors" Science (1988) 239:783-785.
Seyedin et al., "Cartilage-inducing factor .beta. is a unique protein structurally and functionally related to transforming growth factor-.beta." J. Biol. Chem. (1987) 262:1946-1949.
Sing et al., "Transforming growth factor .beta. selectively inhibits normal and leukemic human bone marrow cell growth in-vitro" Blood (1988) 72:1504-1511.
Wahl et al., "Transforming growth factor type .beta. induces monocyte chemotaxis and growth factor production" Proc Natl. Acad. Sci. USA (1987) 84:5788-5792.
Flanders et al., "Antibodies to peptide determinants in transforming growth factor .beta. and their applications" Biochem. (1988) 27:739-746.
Massague, "The TFG-.beta. fanily of growth and differentiation factors" Cell (1987) 49:437-438.
Testa et al., "The biology of long-term bone marrow cultures and its application to bone marrow transplantation" Curr. Opinion Oncol. (1991) 3:272-278.
Berenson et al., "Engraftment after infusion of CD34 .sup.+ marrow cells in patients with breast cancer or neuroblastoma" Blood (1991) 77:1717-1722.
Eaves et al., "In vitro culture of bone marrow cells for autografting in CML" Leukemia (1993) 7:S126-S129.
Dasch James R.
Pace, III Doran R.
Waegell Wendy O.
Budens Robert D.
Celtrix Pharmaceuticals Inc.
LandOfFree
Monoclonal antibodies to transforming growth factor-beta and met does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Monoclonal antibodies to transforming growth factor-beta and met, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Monoclonal antibodies to transforming growth factor-beta and met will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1644286