Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1988-04-26
1993-07-06
Lacey, David L.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
53038826, 5303893, 424 858, 435 7021, 4351722, 43524027, 935104, 935107, C07K 1528, A61K 39395, C12N 520
Patent
active
052255409
ABSTRACT:
High-affinity murine monoclonal antibodies to t-PA were prepared which prolong the in vivo functional half-life of t-PA without decreasing its plasminogen-activator activity.
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Reilly, T. M. et al., Characterization of a panel of monoclonal antibodies against human tissue-type plasminogen activator. 1988, Hybridoma 7(2):177-184.
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Reilly, T. M. et al., Monoclonal antibodies to tissue-type plasminogen activator which prolong its clearance in vivo 1989, Thromb. Haemostasis 61(2):259-261.
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Chiu Andrew T.
Knabb Robert M.
Reilly Thomas M.
Budens Robert D.
Du Pont Merck Pharmaceutical Company
Ferguson Blair Q.
Lacey David L.
Richter Annette L.
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