Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1995-06-07
1999-02-09
Green, Lora M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
5303881, 5303891, 5303892, C07K 1600
Patent
active
058696229
ABSTRACT:
The present invention relates to the PUR protein, nucleotide sequences and expression vectors encoding PUR, and to methods for inhibiting PUR activity. More specifically, the invention relates to polyclonal and monoclonal antibodies that bind PUR or PUR related proteins. Antibodies that bind PUR protein and which neutralize. PUR activity may be used to treat hyperproliferative diseases such as cancer.
REFERENCES:
Wobbe et al., 1987, "Replication of Simian Virus 40 Origin-containing DNA vitro Purified Protein"Proc. Natl. Acad. Sci. USA 84:1834-1838.
Traut, W. and Fanning, E., 1988, "Sequence Specific Interactions Between a Cellular DNA-binding Protein and the Simian Virus 40 Origin of DNA Replication" Mol. Cell. Biol. 8:903-911.
Vassilev, L. and Johnson, E.M. 1989, "Mapping Initiation Sites of DNA Replication in vivo Using Polymerase Chain Reaction Amplification of Nascent Strand Segments" Nucl. Acids Res. 17:7693-7705.
Caddle, M.S. et al, 1990, "Intramolecular DNA Triplexes, Bent DNA and DNA Unwinding Elements in the Initiation Region of an Amplified Dihydrofolate Reductase Replicon" J. Mol. Biol. 211:19-33
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Hofmann, J. F.-X. and Gasser, S.M., 1991, "Identification and Purification of a Protein that Binds the Yeast ARS Consensus Sequence" Cell 64:951-960.
Gutierrez et al., 1991, "Mechanism of Stimulation of DNA Replication by Bacteriophage .o slashed.29 Single-Standed DNA-binding Protein p5" J. Biol. Chem., 266:2104-2111.
Erdile et al., 1991, "Characterization of a cDNA Encoding the 70-kDa Single-stranded DNA-binding Subunit of Human Replication Protein A and the Role of the Protein in DNA Replication" J. Biol. Chem., 266:12090-12098.
Bergemann, A.D. and Johnson, E.M., 1992, "The HeLa PUR Factor Binds Single-Stranded DNA at a Specific Element Conserved in Gene Flanking Regions and Origins of DNA Replication" Mol. Cell. Biol. 12:1257-1265.
Bergemann, A.D. and Johnson, E.M., 1992, "Sequence of cDNA Comprising the Human pur Gene and Sequence-Specific-Single-Stranded-DNA-Binding Properties of the Encoded Protein" Mol. Cell. Biol. 12:5673-5682.
Campbell AM, 1984. Monoclonal antibody technology, Amsterdam: ELsevier pp. 29-30, 1984.
Bergemann Andrew D.
Johnson Edward M.
Green Lora M.
Mount Sinai School of Medicine of the City University of New Yor
Ricigliano Joseph W.
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