Monoclonal antibodies to the L6 glycolipid antigenic determinant

Details Monoclonal antibodies to the L6 glycolipid antigenic determinant Monoclonal antibodies to the L6 glycolipid antigenic determinant

1984-12-21

1990-06-19

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530389, 530391, 530806, 530828, 43524029, 4351722, 435 7, 436548, 935 95, A61K 39395, C07K 1514, C12N 500

Patent

active

049354957

ABSTRACT:
The present invention is concerned with novel monoclonal antibodies which define a gylcolipid antigen associated with human non-small cell lung carcinomas ("NSCLC") and certain other human carcinomas. The antibodies bind to normal human cells to a much lesser degree than to tumor cells. The antibodies find use in diagonostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods. The invention also comprises a method for determining the presence of a malignant condition in lung tissue and other human tissue. The method involves examining the human tissue for the presence of a glycolipid antigen having the characteristics of a ganglio-N-triosylceramide.

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