Monoclonal antibodies to the fibronectin binding protein and...

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds bacterium or component thereof or substance produced...

Reexamination Certificate

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C424S130100, C424S135100, C424S141100, C424S142100, C424S150100, C424S165100, C424S243100, C435S975000, C435S007100, C530S387300, C530S387100, C530S388150, C530S388100

Reexamination Certificate

active

07115264

ABSTRACT:
Monoclonal antibodies which can bind to the Fnbp protein ofStaphylococcus aureusand which are generated from a peptide from the D2 region of fibronectin binding protein B (Fnbp) ofS. aureusare provided which can be useful in the treatment and protection against infection from staphylococcal bacteria such asStaphylococcus aureus. The monoclonal antibodies of the invention are advantageous in that they bindS. aureusin high affinity and thus can be useful in the prevention of the adherence of staph bacteria to host cells by impairing or inhibiting the ability ofS. aureusFnbp to bind to fibronectin. Kits and methods of utilizing the monoclonal antibodies of the invention are also provided.

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