Monoclonal antibodies to the APO-1 antigen

Details Monoclonal antibodies to the APO-1 antigen Monoclonal antibodies to the APO-1 antigen

1995-03-23

1999-04-06

Stucker, Jeffrey

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

435 7021, 4351722, 43524027, 4341521, 4341531, 4341541, 4341551, 4341561, 4341721, 4341731, 4341741, 4342771, 5303871, 5303873, 53038875, 5303888, 53038885, 5303897, A61K 39395, A61K 3900, C12P 2104, C07K 1600

Patent

active

058914340

ABSTRACT:
The APO-1 cellular membrane antigen, an about 50 kDa antigen associated with cellular apoptosis, and purified cDNA encoding same is described. The antigen is expressed by numerous normal and malignant cells, including activated and malignant lymphoid cells. Also disclosed are antibodies which bind the antigen, and which induce growth inhibition and apoptosis.

REFERENCES:
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Trauth et al., "Monoclonal Antibody-Mediated Tumor Regression By Induction of Apoptosis," Science 245:301-305, 21 Jul. 1989.
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