Monoclonal antibodies to superficial papillary bladder tumor cel

Details Monoclonal antibodies to superficial papillary bladder tumor cel Monoclonal antibodies to superficial papillary bladder tumor cel

1987-09-28

1991-08-13

Kepplinger, Esther L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530387, 530808, 935104, C12N 512, C07K 1528

Patent

active

050396110

ABSTRACT:
There is provided four distinct hybrid cell lines bearing numbers M75, M300, M344 and 19A211, each producing a different monoclonal antibody of class lgG1, each antibody when used alone or in combination with one or more of the other three antibodies being capable of selective binding with one or more distinct antigens produced by superficial papillary bladder tumors of the human urinary bladder. There is also provided a method for producing such cell lines as well as a method and a test kit for the detection of distinct antigens produced by superficial papillary bladder turmors of the human urinary bladder. Provision is also made for use in flow cytometry (single or multiple laer) and in biosensors for detect of these antigens.

REFERENCES:
Duncan et al. (1984) Anal. Biochem. 112, 195-203.
Shulman et al. (1978) Nature (London) 276, 269-270.
Hsu et al. (1981), J. Histochem. Cytochem. 29, 577-580.
H. Ben-Aissa et al., "Specificites and Bindings Properties of 2 Monoclonal Antibodies Against Carcinoma Cells of the Human Urinary Bladder", Br. J. Can., 52:65-72 (1985).
Huland et al., "Human Transitional Cell Carcinoma in the NMRI-nu
u Mouse Bladder: A New Animal Model for the In Vivo Use of Monoclonal Antibodies and Cytotoxic Agents", Can. Res. 46:2488-89 (1986).
Frodet et al., "Polymorphic Expression of a Human Superficial Bladder Tumor Antigen Defined by Mouse Monoclonal Antibodies", Proc. Natl. Acad. Sci.; 84:7227-7231 (1987).
Anal. Biochem., Duncan et al., (1984), 138:144-145.
Nature, Shulman et al., (1978), 276:269-270.
J. Histochem. Cytochem., Hsu et al., (1981), 29:577-580.
Proc. Natl. Acad. Sci. U.S.A., Fradet et al., (1984), 81:224-228.
Cancer Research, Lin and Prout, (1985), 45:5070-5079.
J. Exp. Med., Ueda et al., (1979), 150:564-579.
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