Monoclonal antibodies to specific antigenic regions of the human

Details Monoclonal antibodies to specific antigenic regions of the human Monoclonal antibodies to specific antigenic regions of the human

1987-10-07

1992-04-14

Nucker, Christine

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

43524027, 435974, 435975, 5303879, 53038835, G01N 33569

Patent

active

051047900

ABSTRACT:
Monoclonal antibodies capable of binding antigenic determinants within regions of the core proteins of the Human Immunodeficiency Virus and immortalized cell lines producing those monoclonal antibodies are provided. The monoclonal antibodies find use in a variety of ways, including HIV antigen detection in biological samples. Using these methods, individuals may be identified who are infected with HIV but who have not yet developed anti-HIV antibodies. The methods also find use in monitoring in vitro growth of HIV, and the efficacy of therapeutic agents and vaccines.

REFERENCES:
patent: 4629783 (1986-12-01), Cosand
patent: 4753873 (1988-06-01), Beltz et al.
patent: 4755457 (1988-07-01), Robert-Guroff et al.
patent: 4843011 (1989-06-01), Sarngadharan et al.
patent: 4888290 (1989-12-01), Kortright et al.
Chassagne et al., "A Monoclonal Antibody Against LAV `GAG` Precursor: Use For Viral Protein Analysis and Antigenic Expression in Infected Cells" J. Immunol., 136(4) 1442-1445 (1986).
Chang et al., "Expression in Escherichia coli of Open Reading Frame Gene Segments of HTLV-III", Science (1985) 228:93-96.
Steimer et al., "Differential Antibody Responses of Individuals Infected With Aids-Associated Retroviruses Surveyed Using the Viral Core Antigen p. 25 GAG Expressed in Bacteria", Virol. 150 (1986) pp. 283-290.
Robert-Guroff et al., "HTLV-III--Neutralizing Antibodies in Patients With Aids-Related Complex," Nature 316 (1985) 72-4.
Veronese et al., "Monoclonal Antibodies Specific for p. 24, the Major Core Protein of Human-T-Cell Leukemia Virus Type III", Proc. Natl. Acad. Sci. U.S.A., 82(1985) 5199-5202.
Kanner et al., "Human Retroviral env and gag Polypeptides: Serologic Assays to Measure Infection", J. Immunol. 137(1986) 674-678.
Dowbenko et al., "Bacterial Expression of the Acquired Immunodeficiency Syndrome Retrovirus p. 24 gag Protein and Its Use as a Diagnostic Reagent", Proc. Natl. Acad. Sci. U.S.A., 82(1985) 7748-52.

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