Monoclonal antibodies to salinomycin and method for detecting th

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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530808, 530809, 435 792, 43524027, 435810, 435975, C07K 1600, C12N 518

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054667844

ABSTRACT:
Hybridoma cell lines have been produced which produce and secrete monoclonal antibodies which bind salinomycin and are effective to detect salinomycin levels as low as about 0.174 to about 0.793 ng. These monoclonal antibodies may be used for the detection and quantitative determination of very low levels of salinomycin in samples, especially in animal tissue and feed material.

REFERENCES:
patent: 4474893 (1984-10-01), Reading
patent: 4722899 (1988-02-01), Hamaoka et al.
Sevier et al., Clinical Chemistry, vol. 27, No. 11 pp. 1797-1806 (1981).
Clark et al., Hybridoma (3,1, p. 81) 1984.
Miller, Glenn A., et al., "Production of Monoclonal Antibodies to Salinomycin", Hybridoma, vol. 6, No. 4, 1986.
Beier, R. C., et al., "Enzyme Immunoassay for Detection of the Poultry Coccidiostat Salinomycin", Poultry Science, PSA and SPSS Abstracts, vol. 70, Supplement 1, 1991, Eightieth Annual Meeting of the Poultry Sci. Assoc., Aug. 12-16, 1991, Texas A&M Univ, College Station, Tex.

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