Monoclonal antibodies to pseudomonas aeruginosa flagella

Details Monoclonal antibodies to pseudomonas aeruginosa flagella Monoclonal antibodies to pseudomonas aeruginosa flagella

1986-12-24

1989-05-30

Warden, Robert J.

Drug, bio-affecting and body treating compositions

Lymphokine

435 7, 43524027, 435804, 435875, 436512, 436513, 436519, 436548, 436811, 530387, 935100, 935107, 935108, A61K 3940, G01N 3353

Patent

active

048349763

ABSTRACT:
Cell lines have been produced that secrete monoclonal antibodies capable of binding to the flagellar proteins of selected Pseudomonas aeruginosa strains. Some of these antibodies have been found to be protective against lethal challenges of P. aeruginosa. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections, are included.
Prior to filing this application, the continuous transformed cell lines PaF4 IVE8, FA6 IIG5, 20H11, and 21B8, described herein, were deposited in the America Type Culture Collection and given the designations HB9129, HB9130, CRL 9300, and CRL 9301, respectively.

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