Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1983-12-16
1987-05-19
Kepplinger, Esther M.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
530387, 530808, 436548, 436808, 436813, 935 96, 935101, 935108, 935110, 435 68, 4351722, 435241, 435948, C12N 500, C12N 1500, G01N 3353, C12R 191
Patent
active
046668454
ABSTRACT:
Mouse monoclonal antibodies to several cell antigens of human ovarian, cervical and endometrial carcinomas have been produced and characterized. The distribution of the antigens was determined by mixed hemagglutination assays on 153 normal and malignant cell cultures of various types, and by immunoperoxidase staining of frozen sections of 27 normal adult and 24 fetal tissues. five monoclonal antibodies representative of five classes of mAb raised to restricted ovarian, cervical and endometrial cells were tested extensively producing mAb reactive with cancer but not normal cells. One such mAb, MF116 was readily detected in the spent culture medium of metabolically radiolabeled cells. These antibodies, reacting with relatively restricted cell surface antigens, are useful in the analysis of epithelial cell differentiation, in cancer diagnosis and therapy and in tissue typing of normal or abnormal cells.
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Cordon-Cardo Carlos
Lewis, Jr. John L.
Lloyd Kenneth O.
Mattes M. Jules
Old Lloyd J.
Jay Jeremy
Kepplinger Esther M.
Sloan-Kettering Institute
White John P.
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