Monoclonal antibodies to oncoproteins and methods of making mono

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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4351722, 435 691, 43524027, 536 2353, G01N 3353, C12P 2106, C12N 500, C07K 1600

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active

055632475

ABSTRACT:
Monoclonal receptors raised to immunogenic polypeptides whose amino acid residue sequences correspond to sequences of oncoprotein ligands are disclosed, as are methods for the production of those receptors and products and methods that utilize them. The monoclonal receptors bind both to the oncoprotein ligand and to the immunogenic polypeptide to which the receptors were raised.

REFERENCES:
patent: 5030565 (1991-07-01), Niman
Wong et al, PNAS 78, No. 12: 7412-7416 (1981) Synthetic Peptide Fragment of the SRC Gene.
Niman et al., PNAS-USA 80:4949-4953 (1983).
Newmark News and Views, Nature 305:9 (Sep. 1983).
Baltimore, TBIS 9:137-138 (Apr. 1984).
Egrie, 2 Hybridoma 136 (1983).

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