Monoclonal antibodies to nucleolar protein

Details Monoclonal antibodies to nucleolar protein Monoclonal antibodies to nucleolar protein

1994-02-28

1998-09-22

Spiegel, Carol A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 721, 435 731, 435942, 435975, 436548, 436518, 436808, 436811, 5303881, 53038821, 5303885, G01N 3353

Patent

active

058112472

ABSTRACT:
The invention relates to a hybridoma cell line which produces a monoclonal antibody which cross reacts with both yeast and human fibrillarin. Diagnostic kits are also described. These are useful in diagnosing diseases such as scleroderma.

REFERENCES:
patent: 5310892 (1994-05-01), Aris et al.
Aris et al. J. Cell. Biol. 107: 17-31, 1988.
Lischwe et al. J. Biol. Chem. 260(26):14304-14310, 1985.
Ochs et al. Biol. Cell. 54(2):123-33, 1985.
Christensen et al. Exp. Cell Res. 166: 77-93, 1986.
Schimmang et al, "A yeast nucleolar protein related to mammalian fibrillarin is associated with small nucleolar RNA and is essential for viability", The EMBO Journal, vol. 8, No. 13, pp. 4015-4024, 1989.
R. Henriquez et al, The Journal of Biological Chemistry, vol. 265, No. 4, Feb. 5, 1990, pp. 2209-2215.

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