Monoclonal antibodies to human plasma prekallikrein

Details Monoclonal antibodies to human plasma prekallikrein Monoclonal antibodies to human plasma prekallikrein

1993-02-19

1995-08-22

Lacey, David L.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 7021, 53038825, C07K 1640

Patent

active

054441560

ABSTRACT:
Four novel cell lines, ATCC #HB-8862 through ATCC #HB-8865 produce monoclonal antibody to human plasma prekallikrein. At least three of the antibodies also recognize plasma kallikrein, specifically the heavy chain thereof, and kallikrein-Cl-inhibitor complex; at least one of these three antibodies recognizes kallikrein-alpha.sub.2 -macroglobulin complex and kallikrein-antithrombin III complex. The antibodies do not cross-react with tissue kallikrein. The hybridomas are formed by fusing spleen cells from immunized BALB/c AnSkh mice with SP2/O-Agl4 myeloma cells. Diagnostic and biochemical uses of the monoclonal antibodies are provided.

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