Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1985-03-05
1987-07-07
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 7, 435 68, 4351722, 435240, 435241, 435948, 436548, 436800, 530387, 530388, 935 89, 935 93, 935 95, 935 96, 935 99, 935100, 935104, 935106, 935110, G01N 33577, C12Q 170
Patent
active
046787461
ABSTRACT:
A method for preparing hybrid cell lines (hybridomas) which secrete monoclonal antibody which is group-specific to epizootic hemorrhagic disease virus antigen and which does not react to antigenically-related bluetongue virus antigen is disclosed. The antibody identifies EHDV in infected cell cultures with immunofluorescence and provides a means for ready diagnosis of EHDV in animals.
REFERENCES:
M. M. Jochim and S. C. Jones, "Identification of BT and EHD Viruses by Immunofluorescence with Monoclonal Antibodies," Proceedings of the American Association of Veterinary Laboratory Diagnosticians, pp. 277-286 (1983) (oral presentation, 1983; printed publication mailed to members about Apr. 15, 1984).
American Association of Veterinary Laboratory Diagnosticians, Inc. Newsletter, p. 28 (Mar. 1983).
G. Kohler and C. Milstein, "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity," Nature, vol. 256, pp. 495-497 (1975).
G. Kohler and C. Milstein, "Derivation of Specific Antibody-Producing Tissue Culture and Tumor Lines by Cell Fusion," European Journal of Immunology, vol. 6, pp. 511-519 (1976).
G. Galfre, S. C. Howe and C. Milstein, "Antibodies to Major Histocompatibility Antigens Produced by Hybrid Cell Lines," Nature, vol. 266, pp. 550-552 (1977).
Monoclonal Antibodies, Hybridomas: A New Dimension in Biological Analyses, R. H. Kennett, T. J. McKearn, and K. B. Bechtol, Eds., Plenum Press, New York and London (1980).
M. Shulman, C. D. Wilde, and G. Kohler, "A Better Cell Line for Making Hybridomas Secreting Specific Antibodies," Nature, vol. 276, pp. 269-270 (1978).
M. M. Jochim, T. L. Barber, and B. M. Bando, "Identification of Bluetongue and Epizootic Hemorrhagic Disease Viruses by the Indirect Fluorescent Antibody Procedure," Proceedings of the American Association of Veterinary Laboratory Diagnosticians, pp. 91-103 (1974).
D. W. Verwoerd, H. J. Els, E. M. Devillers, and H. Huisman, "Structure of Bluetongue Virus Capsid," Journal of Virology, vol. 10, pp. 783-794 (1972).
M. M. Jochim and S. C. Jones, "Plaque Neutralization of Bluetongue Virus and Epizootic Hemorrhagic Disease Virus in BHK.sub.21 Cells," American Journal of Veterinary Research, vol. 37, pp. 1345-1347 (1976).
Selected Methods in Cellular Immunology, B. B. Mishell and S. M. Shiigi, Eds., W. H. Freeman and Co., San Francisco, pp. 6-8 (1980).
R. H. Kennett, K. A. Denis, A. S. Tung, N. R. Klinman, "Hybrid Plasmacytoma Production: Fusions with Adult Spleen Cells, Monoclonal Spleen Fragments, Neonatal Spleen Cells and Human Spleen Cells," Current Topics in Microbiological Immunology, vol. 81, pp. 77-91 (1978).
Jochim Michael M.
Jones Suzanne C.
Connor Margaret A.
McConnell David G.
Nucker Christine M.
Silverstein M. Howard
The United States of America as represented by the Secretary of
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