Monoclonal antibodies to cyclosporins

Details Monoclonal antibodies to cyclosporins Monoclonal antibodies to cyclosporins

1988-10-31

1992-12-08

Doll, John J.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

5303889, 935109, 935110, 435 7021, 4351722, 435 71, C12N 520, C07K 1528, G01N 3353

Patent

active

051697734

ABSTRACT:
Novel monoclonal antibodies capable of distinguishing between cyclosporins, e.g. Cyclosporine, and metabolites, e.g. Cyclosporins 17 and 18, are produced, e.g. starting from novel cyclosporins having an activated coupling group, e.g. activated carboxy group, e.g. (i) [(O-succinimidooxysuccinyl)-Thr].sup.2 -Cyclosporine and (ii) [(N-.epsilon.-succinimidooxysuccinyl)-(D)Lys].sup.8 -Cyclosporine. Cyclosporin starting materials required for the production of cyclosporins of type (ii), e.g. [(D)Lys].sup.8 -Cyclosporine are also new and additionally have utility in the preparation of novel labelled cyclosporin derivatives, as well as antibodies and antisera generally. Also claimed are novel antigenic conjugates and hybridoma cell lines used in the production of antibodies and antisera as aforesaid as well as assay kits comprising novel antisera, antibodies and/or labelled cyclosporins as aforesaid.

REFERENCES:
Quesniaux et al., Clinical Chemistry 33(1): 32-37, 1987.
Kipps et al. in Weir et al Eds., "Handbook of Immunology", vol. 4, Blackwell Sci. Publ. 1986.
Donatsch et al. J. Immunoassay 2(1): 19-32 1981.
Quesniaux et al. Immunol. Lett. 9: 99-104 1985.

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