Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1984-01-12
1989-10-10
Teskin, Robin L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
43524026, 43524027, 4351722, 435 7, 530387, 935103, 935104, 935108, 935110, 436548, C12P 2100, C12N 1500, C12N 500, C12Q 100
Patent
active
048731897
ABSTRACT:
Hybrid cell lines which secret monoclonal antibody which is group-specific to bluetongue virus (BTV) antigen and which does not react to antigenically related epizootic hemorrhagic disease virus antigen are disclosed. The antibodies identify BTV in infected cell cultures with immunofluorescence and provide a means for ready diagnosis of BTV in animals.
REFERENCES:
patent: 4465776 (1984-08-01), Cidlowski et al.
F. C. Thomas and D. O. Trainer, "Bluetongue Virus: Some Relationships Among North American Isolates and Further Comparisions with EHD Virus," Can. J. Comp. Med. 35:187-191 (1971).
H. Huismans, C. W. Bremer, and T. L. Barber, "The Nucleic Acid and Proteins of Epizootic Haemorrhagic Disease Virus," Onderstepoort J. Vet. Res. 46: 95-104 (1979).
J. R. White, A. M. Breschkin, and A. J. Della-Porta, "Immunochemical Analyses of Australian Bluetongue Virus Serotypes Using Monoclonal Antibodies," Bluetongue and Related Orbiviruses, Alan R. Liss, Inc., pp. 397-405 (1985).
M. J. Grubman, J. A. Appleton, and G. J. Letchworth, III, "Identification of Bluetongue Virus Type 17 Genome Segments Coding for Polypeptides Associated with Virus Neutralization and Intergroup Reactivity," Virology 131: 355-366 (1983).
J. A. Appleton and G. J. Letchworth, "Monoclonal Antibody Analysis of Serotype-Restricted and Unrestricted Bluetongue Viral Antigenic Determinants," Virology, vol. 124, pp. 286-299 (1983).
G. J. Letchworth and J. A. Appleton, "Heterogeneity of Neutralization -Related Epitopes within a Bluetongue Virus Serotype," Virology, vol. 124, pp. 300-307 (1983).
G. Kohler and C. Milstein, "Continuous Cultures of Fused Cells Secretina Antibody of Predefined Specificity," Nature, vol. 256, pp. 495-497 (1975).
G. Kohler and C. Milstein, "Derivation of Specific Antibody-Producing Tissue Culture and Tumor Lines by Cell Fusion," European Journal of Immunology, vol. 6, pp. 511-519 (1976).
G. Galfre, S. C. Howe and C. Milstein, "Antibodies to Major Histocompatibility Antigens Produced by Hybrid Cell Lines," Nature, vol. 266, pp. 550-552 (1977).
Monoclonal Antibodies, Hybridomas: A New Dimension in Biological Analysis, R. H. Kennett, T. J. McKearn, and K. B. Bechtol, Eds., Plenum Press, NY and London (1980).
M. Shulman, C. D. Wilde, and G. Kohler, "A Better Cell Line for Making Hybridomas Secreting Specific Antibodies," Nature, vol. 276, pp. 269-270 (1978).
M. M. Jochim, T. L. Barber, and B. M. Bando, "Identification of Bluetongue and Epizootic Hemorrhagic Disease Viruses by the Indirect Fluorescent Antibody Procedure," Proceedings of the American Association of Veterinary Laboratory Diagnosticians, pp. 91-103 (1974).
D. W. Verwoerd, H. J. Els, E. M. DeVilliers, and H. Huismans, "Structure of Bluetongue Virus Capsid," Journal of Virology, vol. 10, pp. 783-794 (1972).
M. M. Jochim and S. C. Jones, "Plaque Neutralization of Bluetongue Virus and Epizootic Hemorrhagic Disease Virus in BHK.sub.21 Cells," American Journal of Veterinary Research, vol. 37, pp. 1345-1347 (1976).
Selected Methods in Cellular Immunology, B. B. Mishell and S. M. Shiigi, Eds., W. H. Freeman and Co., San Francisco, pp. 6-8 (1980).
R. H. Kennett, K. A. Denis, A. S. Tung, N. R. Klinman, "Hybrid Plasmacytoma Production: Fusions with Adult Spleen Cells, Monoclonal Spleen Fragments, Neonatal Spleen Cells and Human Spleen Cells," Current Topics in Microbiological Immunology, vol. 81, pp. 77-91 (1978).
Campbell et al., Vet Microbiol, vol 361, 1978 pp. 15-22 "Antigenic Relationship of Ibarakiving Bluetongue Virus and Epizootic Hemorrhagic Disease Virus".
Huismans et al., Onaerstepoort T. Vet. Res., vol. 48, pp. 59-67, 1981.
Wiktor et al., T. Virol Methods vol. 1, pp. 33-46, 1980 "Use of Monoclonal Antibodies in the Diagnosis of Rabies Virus infection and Differentiation of Rabies and Rabies-Related Viruses".
Jochim Michael M.
Jones Suzanne C.
Connor Margaret A.
Silverstein M. Howard
Teskin Robin L.
The United States of America as represented by the Secretary of
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